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Maternal occlusal disharmony produces the learning deficits by the altered hippocampal neurogenesis, enriched enviroment of pups ameliorates the learning deficits

Research Project

Project/Area Number 24593113
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionAsahi University

Principal Investigator

Iinuma Mitsuo  朝日大学, 歯学部, 教授 (70184364)

Co-Investigator(Kenkyū-buntansha) KUBO Kin-ya  星城大学, リハビリテーション学部, 教授 (00329492)
TAMURA Yasuo  朝日大学, 歯学部, 教授 (40113047)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords妊娠中の咬合障害 / 仔マウス / 飼育環境良好 / 海馬機能 / 空間認知能 / 飼育環境 / ストレス抑制 / 神経細胞 / 細胞分化 / アストロサイト / BDNF / 養育環境 / 歯の喪失 / 老化促進モデルマウス / 水迷路テスト / 海馬新生細胞 / 胎生期ストレス / 生後発達障害 / 海馬
Outline of Final Research Achievements

To determine which aspect of neurogenesis regulation is influenced in the hippocampus of pups obtained from dams in the bite-raised condition during pregnancy, we examined the proliferation of newborn cells in the pup hippocampus and spatial learning ability.
Plasma corticosterone levels of bite-raised group in dam were greater than those of the control group. The dams of maternal bite-raised condition was decreased the proliferation of newborn cells in the pup hippocampus and spatial learning ability. Exposure to an enriched environment enhances, hippocampal cell proliferation and spatial learning ability were improved.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2015 2014 2013 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Tooth loss early in life accelerates aged-related bone deterioration in mice2015

    • Author(s)
      Minori kurahashi, Hiroko Kondo, Mitsuo Iinuma, Yasuo Tamura, Huayue
    • Journal Title

      Tohoku J.Exp.Med

      Volume: 237(1) Pages: 29-37

    • NAID

      130004822425

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chewing maintains hippocampus-dependent cognitive function2015

    • Author(s)
      )Huayue Chen, Mitsuo Iinuma, Minoru Onozuka and Kin-ya Kubo
    • Journal Title

      International Journal of Medical Science

      Volume: 26(3) Pages: 502-509

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hippocampus-dependent spatial memory impairment due to molar tooth loss is ameliorated by an enriched emvironment2015

    • Author(s)
      Kondo H,Kurahashi M,Mori D, IinumaM他6名
    • Journal Title

      Archives of Oral Biology

      Volume: 61 Pages: 1-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Relationship between the Early Toothless Condition and HippocampalFunctional Morphology2014

    • Author(s)
      M Iinuma, H Kondo, M Kurahashi, M Onishi, Y Tamura, H Chen and K Kubo
    • Journal Title

      Anatomy and Physiology

      Volume: 4

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Maternal chewing during prenatal stress ameliorates stress-induced deficits in myelin formation in the hippocampus in adult pups2015

    • Author(s)
      A Suzuki, M Kotachi, M Iinuma 他6名
    • Organizer
      第37回日本神経科学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] Maternal occlusal disharmony suppresses cell proliferation in the hippocampus of pups2015

    • Author(s)
      Mitsuo Iinuma, Sakae Mori, Hiroko Kmondo, Chika Murabayashi, Yasuo Tamura and Kin-ya Kubo
    • Organizer
      25th Congress of International Association of Pediatric Dentistrt
    • Place of Presentation
      Glasgow,UK
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 歯の喪失により惹起される海馬機能障害は豊かな飼育環境により改善される2015

    • Author(s)
      近藤裕子、倉橋実里、鈴木あゆみ、小刀見佳、村林知香、森大輔、飯沼光生、田村康夫、久保金弥。
    • Organizer
      第53回日本小児歯科学会
    • Place of Presentation
      広島
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 飼育環境が歯の喪失により惹起された空間認知能に与える影響2014

    • Author(s)
      近藤裕子、尾辻渉、倉橋実里、大西見佳、鈴木あゆみ、村林知香、飯沼光生、田村康夫、森大輔、久保金弥
    • Organizer
      第52回日本小児歯科学会
    • Place of Presentation
      東京、品川区立総合区民会館
    • Year and Date
      2014-05-16
    • Related Report
      2014 Research-status Report
  • [Presentation] Effects of maternal occlusal stress on hippocampal neurogenesis in SAM mouse pups2013

    • Author(s)
      M Iinuma, H Kondo, M Kurahashi, M Onishi, Y Tamura and K Kubo
    • Organizer
      24th International Association of Pediatric Dentistry
    • Place of Presentation
      韓国ソウルcoex
    • Related Report
      2012 Research-status Report
  • [Presentation] 環境強化は歯の喪失によって惹起される認知障害を改善させる

    • Author(s)
      近藤裕子
    • Organizer
      第51回日本小児歯科学会
    • Place of Presentation
      岐阜長良川国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] Effects of maternal occlusal stress on hippocampal neurogenesis in SAM mouse-pups

    • Author(s)
      飯沼光生
    • Organizer
      24th Congress of International Association of Pedoatric Dentistry
    • Place of Presentation
      Korea
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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