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The exploitation of effective tooth movement by the specific osteoclast inhibitor and the system of prevention on periodontal disease.

Research Project

Project/Area Number 24593115
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionAichi Gakuin University

Principal Investigator

GOTO Shigemi  愛知学院大学, 歯学部, 教授 (60142577)

Co-Investigator(Kenkyū-buntansha) MIYAZAWA Ken  愛知学院大学, 歯学部, 教授 (60301636)
Co-Investigator(Renkei-kenkyūsha) TABUCHI Masako  愛知学院大学, 歯学部, 講師 (30418925)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords歯学 / 矯正学 / 歯周病 / 破骨細胞 / 病理学
Outline of Final Research Achievements

The purpose of this study is making a system which is controlled tooth movement freely by the bone metabolism and controlled resorption of alveolar bone in periodontal disease. Firstly, it was established an experimental mouse model of periodontitis-inducing. This research suggested that placement of the ligature wire around the contact point between teeth was successfully induced alveolar bone resorption. Therefore, the present report provides a new animal model of periodontitis.
Further studies are needed to investigate and development the system of tooth movement controlled by the bone metabolism.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (7 results)

  • [Journal Article] A New Experimental Mouse Model of Periodontitis Using an Orthodontic Ligature Wire2014

    • Author(s)
      Mizuno M, Miyazawa K, Tabuchi M, Tanaka M, Yoshizako M, Yamane C, Torii Y, Maeda H, Goto S
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 23 Issue: 2 Pages: 255-260

    • DOI

      10.2485/jhtb.23.255

    • NAID

      130004480661

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Midpalatal miniscrews and high-pull headgear for anteroposterior and vertical anchorage control: Cephalometric comparisoms of treatment changes.2013

    • Author(s)
      Jungkil Lee,Ken Miyazawa Masako Tabuti, Misuzu Kawaguchi, Momoko Shibata, and Shigemi Goto
    • Journal Title

      Am J Orthod Dentofacial Orthop

      Volume: 144 Issue: 2 Pages: 238-250

    • DOI

      10.1016/j.ajodo.2013.03.020

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 破骨細胞特異的抑制剤(ReveromycinA)を用いた歯の移動のコントロールについて2014

    • Author(s)
      源 千里,宮澤 健,田渕雅子,藪本貴洋,田中美由紀,水野愛実,吉廻 守,鳥井康義,玉岡佑将,川谷 誠,長田裕之,後藤滋巳
    • Organizer
      第73回日本矯正歯科学会大会
    • Place of Presentation
      幕張
    • Year and Date
      2014-10-20 – 2014-10-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] The effects of reveromycin A on the continuous tooth movement of OPG knockout mice2014

    • Author(s)
      Miyazawa K, Tabuchi M, Goto S
    • Organizer
      The 45th Italian Society of Orthodontics International Congress
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2014-10-09 – 2014-10-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] A comparative study of fluoride release from glass ionomer cement2014

    • Author(s)
      Goto S, Igami S, Miyazawa K
    • Organizer
      The 45th Italian Society of Orthodontics International Congress
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2014-10-09 – 2014-10-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of NdFeB magnets for bringing an impacted teeth on typodont model2014

    • Author(s)
      Goto S, Hata Y, Hida M, Miyazawa K
    • Organizer
      The 90th Congress of The European Orthodontic Society
    • Place of Presentation
      Warsaw, Poland
    • Year and Date
      2014-06-18 – 2014-06-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 持続的矯正力における, 破骨細胞特異的薬剤(リベロマイシンA)による歯牙移動のコントロールについて2013

    • Author(s)
      山根千里,宮澤 健,田渕雅子,田中美由紀,水野愛実,吉廻 守,鳥井康義,川谷 誠,長田裕之,後藤滋巳
    • Organizer
      第72回日本矯正歯科学会大会
    • Place of Presentation
      キッセイ文化ホール(松本)
    • Related Report
      2013 Research-status Report
  • [Presentation] 若年性骨Paget病の病態に類似したOPG -/- miceの全身的な骨構造, 機械的強度の検討2013

    • Author(s)
      吉廻 守,宮澤 健,田渕雅子,水野愛実,山根千里,鳥井康義,後藤滋巳
    • Organizer
      第72回日本矯正歯科学会大会
    • Place of Presentation
      キッセイ文化ホール(松本)
    • Related Report
      2013 Research-status Report
  • [Presentation] Reveromycin A treatment during experimental tooth movement under continuous orthodontic foce.2012

    • Author(s)
      Goto S, Tanaka M, Tabuchi M, Kawatani M, Osada H
    • Organizer
      American Association of Orthodontists
    • Place of Presentation
      United States
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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