| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
To clarify the mechanism of cleft palate, we studied about palatal development of mice embryo using histological analysis. We focused on disappearing process of medial edge epithelium (MEE) during palatal shelves fusion. The intra-cellular signaling of TGF-beta which is critical factor for disappearing of MEE, were different between hard and soft region of palatal shelves. Furthermore, Tenascin C expression in palatal mesenchyme induced after basal membrane changing during MEE disappearing, was regulated by TGF-beta signalind, and specially observed in soft palate region. Our data suggested that the extra cellular matrix expression in palatal mesenchyme was differentially regulated by TGF-beta signaling between anterior and posterior of MEE.
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