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Elevated expression of Alzheimer disease related genes in periodontiti-affected gingival tissues

Research Project

Project/Area Number 24593119
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontal dentistry
Research InstitutionNiigata University

Principal Investigator

Kubota Takehiko  新潟大学, 医歯学総合病院, 講師 (50303136)

Co-Investigator(Kenkyū-buntansha) MARIYAMA SATOSHI  新潟大学, 医歯学総合病院, 講師 (30397161)
中曽根 直弘  新潟大学, 医歯学総合病院, 医員 (20447634)
Co-Investigator(Renkei-kenkyūsha) NOUNO KANAME  新潟大学, 医歯学系, 助教 (80422608)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords医療・福祉 / 歯学 / 免疫学 / 病理学 / 遺伝子発現 / タンパク質局在 / 歯周病 / アルツハイマー病
Outline of Final Research Achievements

We have first reported that the significantly elevated expression of Amyloid beta (A4) precursor protein (APP) transcript levels in human periodontitis-affected gingival tissues. It was also identified that the APP-expressing cells in inflamed gingival tissues were mainly macrophages (Archs Oral Biol 2014). Secondary, significantly upregulated genes including MD-2, CD14, IL-1beta, IL-8 and CXCL-9, which belongs to toll-like receptor (TLR) signaling pathway were also found in periodontitis-affected gingival tissues. It was reported and published in Opn J Stomatol 2014.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2016 2015 2014 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Amyloid beta (A4) precursor protein expression in human periodontitis-affected gingival tissues.2014

    • Author(s)
      Kubota T, Maruyama S, Abe D, Tomita T, Morozumi T, Nakasone N, Saku T, Yoshie H.
    • Journal Title

      Arch Oral Biol.

      Volume: 59(6) Issue: 6 Pages: 586-94

    • DOI

      10.1016/j.archoralbio.2014.03.004

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 歯周病・歯周治療に対する疑問に答えるー明日から役立つー 歯周基本治療・歯周再生治療・インプラント・全身疾患2016

    • Author(s)
      久保田健彦
    • Organizer
      群馬県藤岡市歯科医師会学術講演会
    • Place of Presentation
      藤岡商工会議所 ( 群馬県藤岡市)
    • Year and Date
      2016-01-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 歯周炎罹患歯肉組織におけるNeprilysin(Alzheimer病関連遺伝子)の発現2015

    • Author(s)
      根津新、久保田健彦、丸山智、永田昌毅、堀水慎、濃野要、保苅崇大、両角俊哉、朔敬、 吉江弘正
    • Organizer
      第58回秋季日本歯周病学会学術大会
    • Place of Presentation
      アクトシティ浜松 (静岡県浜松市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Alzheimer’s diseases-related gene and protein expressions in periodontitis-affected gingival tissues2015

    • Author(s)
      Kubota T, Nezu A, Maruyama S, Horimizu M, Nohno K, Hokari T, Morozumi T, Saku T, Yoshie H
    • Organizer
      Europerio 8
    • Place of Presentation
      London , UK
    • Year and Date
      2015-06-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Amyloid beta (A4) precursor protein expression in periodontitis-affected gingival tissues2012

    • Author(s)
      Kubota T, Mauyama S, Abe D, Shimizu T, Nakasone N, Morozumi T, Saku T, Yoshie H
    • Organizer
      The 98th Annual Meeting American Academy of Periodontology in collaboration with the Japanese Society of Periodontology (Research Forum Poster Session)
    • Place of Presentation
      Los Angeles, U.S.A.
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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