The regulatory mechanism of function on gingival epithelium by irsogladine maleate
| Project/Area Number |
24593123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUDA Shinji 広島大学, 病院, 病院助教 (30611321)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯周病予防 / 歯肉上皮 / アポトーシス / イルソグラジンマレイン酸 / IL-8 / smad2 / ERK / 歯周病原細菌 / 歯肉上皮細胞 / smad2リン酸化 / TGF-betaレセプター / アポトーシスシグナル |
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| Outline of Final Research Achievements |
Smad2 was involved in Aggregatibacter actinomycetemcomitans-induced apoptosis in human gingival epithelial cells. In addition, irsogladine maleate, amphotericin B, azithromycin, and Houttuynia cordata down-regulated A. actinomycetemcomitans-induced increase of IL-8 through ERK signaling in human gingival epithelial cells. These findings suggested that the regulation of these cascades may lead the prevention of periodontal disease by regulating the function of gingival epithelium.
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Report
(4 results)
Research Products
(11 results)
