| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Bacterial components in dental plaque activate innate immune system via receptors, such as Toll-like receptors (TLRs). To control the inflammatory responses in periodontal tissue, we analyzed TLR2- and TLR4-stimulating ability of supra- and subgingival plaque. We found that proinflammatory cytokine production by peripheral blood mononuclear leukocytes is mainly mediated by TLR4.
Controlling TLR4-stiulating ability of supra- and subgingival plaque might be useful for preventing the progression of periodontal diseases.
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