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Healing response to initial periodontal therapy based on GCF profiling

Research Project

Project/Area Number 24593129
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontal dentistry
Research InstitutionKyushu Dental College

Principal Investigator

NAKASHIMA KEISUKE  九州歯科大学, 歯学部, 教授 (80227785)

Co-Investigator(Kenkyū-buntansha) OHSHIMA Mitsuhiro  奥羽大学, 薬学部, 教授 (30194145)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords慢性歯周炎 / 歯周治療 / サイトカイン / 歯肉溝滲出液 / 歯周炎 / 該当なし
Outline of Final Research Achievements

The present study aimed to clarify profiles of gingival crevicular fluid (GCF) associated with the healing response to initial periodontal therapy. Ten patients with chronic periodontitis were recruited. A periodontal pocket with the probing depth of 4 mm or greater was selected for each patient and GCF sample was obtained from the pocket. Scaling and root planing (SRP) was performed under local anesthesia. GCF sample was obtained again one week after SRP. The chemiluminescence was detected to measure the levels of cytokines after samples were incubated with an antibody array membrane. This study elucidated that SRP leads to mainly change the level of five cytokines in GCF, IL-1a, IL-8, IL-16, RANTES and TNF-b.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (7 results)

All 2015 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (1 results)

  • [Journal Article] Development of a membrane-based microwave-mediated electrochemical ELISA method for TNF-alpha detection in patients with periodontitis2013

    • Author(s)
      Diala I.
    • Journal Title

      Anal Sci

      Volume: 29 Pages: 927-930

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of Toll-like receptor 2 in apoptosis of Aggregatibacter actinomycetemcomitans-infected THP-1 cells2013

    • Author(s)
      Kato S.
    • Journal Title

      J Microbiol Immunol Infect

      Volume: 46 Issue: 3 Pages: 164-170

    • DOI

      10.1016/j.jmii.2012.02.003

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] New system for detection of oral bacterial adhesion to macrophages in vitro2013

    • Author(s)
      Morishita M.
    • Journal Title

      WebPub J Sci Res

      Volume: 2 Pages: 11-15

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A. actinomycetemcomitans LPS Enhances Foam Cell Formation Induced by LDL2013

    • Author(s)
      Morishita M, Ariyoshi W, Okinaga T, Usui M, Nakashima K, Nishihara T (Morishita)
    • Journal Title

      Journal of Dental Research

      Volume: 92 Issue: 3 Pages: 241-246

    • DOI

      10.1177/0022034512473309

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reflection of 18F-FDG accumulation in the evaluation of the extent of periapical or periodontal inflammation.2012

    • Author(s)
      Kito S, Kitamura C, Morimoto Y, et al.
    • Journal Title

      Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology

      Volume: 114(6): Issue: 6 Pages: 62-69

    • DOI

      10.1016/j.oooo.2012.05.027

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 超高齢社会における非外科的歯周治療の重要性2012

    • Author(s)
      中島啓介
    • Journal Title

      九州歯会誌

      Volume: 65 Pages: 179-184

    • NAID

      10030022188

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 歯周基本治療によるGCF中サイトカイン量の変化2015

    • Author(s)
      稗田祐理子,古賀由貴子,林晃一郎,花谷智哉,中村太志,村岡宏祐,臼井通彦,中島啓介
    • Organizer
      第58回春季日本歯周病学会学術大会
    • Place of Presentation
      幕張メッセ,千葉県・千葉市
    • Year and Date
      2015-05-15 – 2015-05-16
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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