Production of the inflammatory periodontal disease model by the enhanced MAPK signaling
| Project/Area Number |
24593132
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
KOIDE Masanori 松本歯科大学, 総合歯科医学研究所, 講師 (10367617)
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| Co-Investigator(Kenkyū-buntansha) |
NINOMIYA Tadashi 松本歯科大学, 総合歯科医学研究所, 講師 (00360222)
UDAGAWA Nobuyuki 松本歯科大学, 歯学部, 教授 (70245801)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯周病 / 歯周病モデル / 歯槽骨吸収 / MAPK / OPG / 歯周免疫機能学 / 歯学 / 免疫学 / 応用動物 / 炎症性歯周病モデル / トランスレーショナルリサーチ |
|---|
| Outline of Final Research Achievements |
Periodontitis is caused a chronic inflammatory disease by bacteria infection. But, the condition of a patient is complicated, and pathological condition of periodontitis is not understood well enough. Elucidation of the inflammation of host side is important to progress treatment of periodontitis. MAPK is an intracellular signal transduction of an inflammation. Deficiency of MAPK phosphatase-1 (MAPK inactivating gene, MKP-1) activates constantly inflammation. MKP-1-deficient mice exhibited high sensitivity of inflammation. OPG-deficient mice exhibited severer alveolar bone loss. Our aiming was establishment of the accelerated periodontitis model that reflected the pathological condition. (Result) I got the MKP-1 and OPG double deficient (dKO) mice. The alveolar bone loss is more severe in MKP-1 and OPG dKO mice than OPG-deficient mice using analysis of micro CT.
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Report
(4 results)
Research Products
(15 results)
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[Book] 慢性疾患としての歯周病へのアプローチ，第Ⅰ章 4歯槽骨への炎症の波及2014
Author(s)
小出雅則, 野口俊英, 林潤一郎, 福田光男, 稲垣幸司, 石原裕一, 三谷章雄, 亀井英彦, 祖父江尊範, 松原達昭，成瀬桂子, 松下健二, 山下明子，西村英紀, 坂野雅洋, 菊池 毅，杉村 達, 相野 誠, 花田信弘, 船越栄次 他
Publisher
医歯薬出版株式会社
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