| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Periodontitis is caused a chronic inflammatory disease by bacteria infection. But, the condition of a patient is complicated, and pathological condition of periodontitis is not understood well enough. Elucidation of the inflammation of host side is important to progress treatment of periodontitis. MAPK is an intracellular signal transduction of an inflammation. Deficiency of MAPK phosphatase-1 (MAPK inactivating gene, MKP-1) activates constantly inflammation. MKP-1-deficient mice exhibited high sensitivity of inflammation. OPG-deficient mice exhibited severer alveolar bone loss. Our aiming was establishment of the accelerated periodontitis model that reflected the pathological condition. (Result) I got the MKP-1 and OPG double deficient (dKO) mice. The alveolar bone loss is more severe in MKP-1 and OPG dKO mice than OPG-deficient mice using analysis of micro CT.
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