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Investigating the Alveolar Bone-Loss Mechanism in Elderly Women, using Ovariectomized Monkey Subjects with Ligature-Induced Periodontitis.

Research Project

Project/Area Number 24593133
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontal dentistry
Research InstitutionAsahi University

Principal Investigator

EJIRI Sadakazu  朝日大学, 歯学部, 教授 (40160361)

Co-Investigator(Kenkyū-buntansha) TANAKA Mikako  新潟大学, 医歯学総合病院, 講師 (20361909)
SIBUTANI Toshiaki  朝日大学, 歯学部, 教授 (40206149)
KOGAYA Yasutoku  朝日大学, 歯学部, 准教授 (30076046)
SATOU Kazuhiko  朝日大学, 歯学部, 講師 (20340078)
WATANABE Ryuuta  朝日大学, 歯学部, 助教 (00586927)
池亀 美華  岡山大学, 医歯(薬)学総合研究科, 准教授 (70282986)
Co-Investigator(Renkei-kenkyūsha) MIKAMI Emi  新潟大学, 医歯学総合病院, 医員 (20149328)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords骨粗鬆症 / 卵巣摘出モデル / 歯槽骨 / 歯周炎 / 卵巣摘出サル / 歯周炎モデル / カテプシンK阻害剤 / サル歯周炎モデル
Outline of Final Research Achievements

In order to elucidate the relationship between post-menopausal osteoporosis and periodontitis, as involved in the mechanism of alveolar bone loss in elderly women, our study investigated microstructural alveolar bone changes occurring in ovariectomized monkeys with and without ligature-induced periodontitis, and also examined the effects of Cathepsin K inhibitor as an anti-bone loss agent in these animals.
Our findings suggest that the local inflammation induced by periodontitis, together with systemic hormonal changes such as estrogen deficiency, may synergistically accelerate alveolar bone loss in elderly women. Furthermore, the results suggest that Cathepsin K inhibitor may also be useful for suppressing bone loss and accelerating alveolar bone formation in elderly women.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2015 2014 2013

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Bisphosphonate 休薬期間が抜歯窩治癒過程に及ぼす影響についての実験的研究2014

    • Author(s)
      伊藤友里、厚地功誠、村木智則、渡邉竜太、笠井唯克、細原政俊、江尻貞一、式守道夫
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 60 Pages: 596-608

    • NAID

      130005092008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Partial albinism in the Japanese shrew mole, Urotrichus talpoides, from Aichi, Japan2014

    • Author(s)
      Moribe J, Yasui K, Inagaki N, Watanabe R, Satoh K, Kogaya Y, Ejiri S
    • Journal Title

      Mammalia

      Volume: 78

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Masseter muscle structure and its relationship with medical chewing movement in Pallas’s squirrel, Callosciurus erythraeus.2014

    • Author(s)
      Satoh K, Yano W, Watanabe R, Kogaya Y, Ejiri S
    • Journal Title

      The Journal of Gifu Dental Society.

      Volume: 40 Pages: 252-257

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlations between alveolar bone microstructure and bone turnover markers in pre- and post-menopausal women2013

    • Author(s)
      Yamashita-Mikami E, Tanaka M, Sakurai N, Arai Y, Matsuo A, Ohshima H, Nomura S, and Ejiri
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol

      Volume: 115(4) Issue: 4 Pages: 12-19

    • DOI

      10.1016/j.oooo.2011.10.028

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] ヒト耳介筋とマウス頸耳介筋の比較解剖学2015

    • Author(s)
      矢野航、渡邉竜太、佐藤和彦、小萱康徳、江尻貞一
    • Organizer
      第120回日本解剖学会総会・全国学実集会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] ラット頭蓋成長に伴う咬筋14区画の力の大きさと方向の変化2014

    • Author(s)
      岩田明子、佐藤和彦、矢野航、北井則行、江尻貞一
    • Organizer
      日本咀嚼学会題25回学術大会
    • Place of Presentation
      静岡
    • Year and Date
      2014-09-20 – 2014-09-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] ビスフォスフォネート休薬後の家兎抜歯窩治癒過程における骨形態計測学的検討2014

    • Author(s)
      厚地功誠、伊藤友里、渡邉竜太、江尻貞一、式守道夫
    • Organizer
      第34回骨形態計測学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2014-06-12 – 2014-06-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Changes In Sclerostin Localization In Alveolar Bones During Tooth Displacement.2013

    • Author(s)
      4. Ryuta Watanabe,Keita Aoki,Atsushi Fujiwara,Wataru Yano,Kazuhiko Satoh,Yasutoku Kogaya,Noriyuki Kitai,Sadakazu Ejiri.
    • Organizer
      2nd Joint Meeting of the International Bone and Mineral Society and the Japanese Society for Bone and Mineral Research.
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2013 Research-status Report
  • [Presentation] メカニカルストレスによって誘導される歯槽骨改造現象の生体力学的・組織学的検索.2013

    • Author(s)
      5. 渡邉竜太,青木啓太,藤原敦,矢野航,佐藤和彦,小萱康徳,江㞍貞一
    • Organizer
      第33回日本骨形態計測学会学術集会
    • Place of Presentation
      アクトシティ浜松コングレスセンター(浜松市)
    • Related Report
      2013 Research-status Report
  • [Presentation] メカニカルストレスによって誘導される歯槽骨リモデリング調節機構の解明2013

    • Author(s)
      渡辺竜太、青木啓太、藤原敦、矢野航、佐藤和彦、小萱康徳、江尻貞一
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      サンポートホール高松・かがわ国際会議場
    • Related Report
      2012 Research-status Report
  • [Book] 口腔顎顔面解剖ノート2014

    • Author(s)
      安藤禎紀、入江一元、宇佐美晶信、江尻貞一、影山幾男、近藤信太郎、佐藤和彦、塩崎一成、野坂洋一郎、松尾雅斗、松永智、渡邉竜太
    • Total Pages
      240
    • Publisher
      学研書院
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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