| Project/Area Number |
24593136
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
FUKUDA Mitsuo 愛知学院大学, 歯学部, 教授 (40156790)
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| Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Toshihide 愛知学院大学, 歯学部, 教授 (50014262)
MITANI Akio 愛知学院大学, 歯学部, 教授 (50329611)
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| Co-Investigator(Renkei-kenkyūsha) |
SATO Takashi 愛知学院大学, 歯学部, 准教授 (00387573)
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| Research Collaborator |
HAYASHI Jun-ichiro 愛知学院大学, 歯学部, 講師 (30350937)
SATO Sato 愛知学院大学, 歯学部, 非常勤助教 (40647054)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 細菌叢 / 歯周病 / 口臭 |
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| Outline of Final Research Achievements |
We focused on tonsil as the source of the re-infection of periodontal pathogen based on oral malodor. Malodor is thought to be early sign of periodontal disease. Orally healthy patients were assigned to one of three groups. The volatile sulfur compounds in mouth air were assessed before and after gargling. For bacterial assessment, biofilm was got from the palatine tonsils. VSC-producing periodontal pathogens were detected in the samples and the bacterial profiles were analyzed by the T-RFLP. Clone libraries of two high malodor patients were sequenced for the T-RFs. Gargling reduced VSCs and the organoleptic score, but did not affect the periodontal pathogens. The T-RFLP analysis showed no significant change in the bacterial profile after gargling, but decrease in some of the T-RFs in the test. The candidate species assigned to these T-RFs contained VSC-producing bacteria such as Veillonella and Prevotella species.
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