| Project/Area Number |
24593139
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
OHGI Kimiko 福岡歯科大学, 口腔歯学部, 助教 (50610979)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAGAMI Ryuji 福岡歯科大学, 歯学部, 教授 (50215612)
OKABE Koji 福岡歯科大学, 歯学部, 教授 (80224046)
NAGAI Atsushi 福岡歯科大学, 歯学部, 教授 (70252989)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 破骨細胞 / 歯周炎 / 脂質異常症 / 歯周病 / Cl-輸送 / 高脂血症 / スタチン / ビスフォスフォネート / whole cell patch clamp |
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| Outline of Final Research Achievements |
Periodontal disease caused by bacterial infection is usually associated with metabolic disease contained with dyslipidemia. It was an aim to clarify what kind of influence osteoclast came under by dyslipidemia.
Both hypolipidemic agent, statin and drug for treatment of osteoporosis, nitrogen-containing bisphosphonates suppressed acid activated Cl- currents using whole cell patch clamp on osteoclasts, meaning inhibition of extruding H+ and Cl- on resorbing bone. Number of osteoclasts was increased by stimulation with the ligands of TLR2 or TLR4 which are receptors of periodontal pathogens, and oxLDL which is receptor caused to dyslipidemia. The result suggested the possibility that bone resorption may be progressing when periodontitis and dyslipidemia are complication.
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