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Development and clinical evaluation of a new electric toothbrush utilizing disinfection technique based on photolysis of hydrogen peroxide

Research Project

Project/Area Number 24593140
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionTohoku University

Principal Investigator

IKAI Hiroyo  東北大学, 歯学研究科(研究院), 助教 (20431588)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsヒドロキシルラジカル / 過酸化水素 / 青色可視光 / 殺菌 / 可視光 / 歯ブラシ
Outline of Final Research Achievements

In order to apply the bactericidal action of photolysis of hydrogen peroxide to a wide range of civilian goods, I have developed the toothbrush that emits blue visible light from the tip of bristle. A compact size LED was fixed with the head of toothbrush by using a weld technology so that the light could be introduced to the tip of bristle. In addition, the content of hydrogen peroxide contained in commercially available toothpastes and the yield of hydroxyl radical generated by the blue light irradiation of these toothpastes were determined. Based on the determinations, an optimal toothpaste was chosen to be used in a future clinical study. Besides these studies, since it was found that addition of proanthocyanidin, a group of polyphenols, augmented the bactericidal action of photolysis of hydrogen peroxide, it was suggested that a novel toothpaste containing proanthocyanidin could be applicable to the light emitting toothbrush.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (23 results)

All 2015 2014 2013 2012

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (13 results)

  • [Journal Article] Synergistic interaction between wavelength of light and concentration of H2O2 in bactericidal activity of photolysis of H2O2.2015

    • Author(s)
      Toki, T., Nakamura, K., Kurauchi, M., Kanno, T., Katsuda, Y., Ikai, H., Hayashi, E., Egusa, H., Sasaki, K., Niwano, Y.
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume: 19(3) Issue: 3 Pages: 1358-1362

    • DOI

      10.1016/j.jbiosc.2014.08.015

    • NAID

      210000004988

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postantibiotic effect of disinfection treatment by photolysis of hydrogen peroxide.2014

    • Author(s)
      Odashima, Y., Nakamura, K., Ikai, H., Kanno, T., Meirelles, L., Sasaki, K., Niwano, Y.
    • Journal Title

      Journal of Chemotherapy

      Volume: 26(2) Pages: 92-100

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postantibiotic effect of disinfection treatment by photolysis of hydrogen peroxide.2014

    • Author(s)
      Odashima, Y., Nakamura, K., Ikai, H., Kanno, T., Meirelles, L., Sasaki, K., Niwano, Y.
    • Journal Title

      Journal of Chemotherapy

      Volume: 26(2): Issue: 2 Pages: 92-100

    • DOI

      10.1179/1973947813y.0000000114

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vitro evaluation of the risk of inducing bacterial resistance to disinfection treatment with photolysis of hydrogen peroxide2013

    • Author(s)
      Ikai, H., Odashima, Y., Kanno, T., Nakamura, K., Shirato, M., Sasaki, K., Niwano, Y
    • Journal Title

      PLoS ONE

      Volume: 8(11) Issue: 11 Pages: e81316-e81316

    • DOI

      10.1371/journal.pone.0081316

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synergistic effect of proanthocyanidin on bactericidal action of photolysis of H2O22013

    • Author(s)
      Ikai, H., Nakamura, K., Kanno, T., Shirato. M., Meirelles, L., Sasaki, K., Niwano, Y.
    • Journal Title

      Biocontrol Science

      Volume: 18(3) Pages: 137-141

    • NAID

      10031202904

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vitro bactericidal activity of photo-irradiated oxydol products via hydroxyl radical generation2013

    • Author(s)
      Oyamada A., Ikai, H., Nakamura, K., Hayashi, E., Kanno, T., Sasaki, K., Niwano, Y.
    • Journal Title

      Biocontrol Science

      Volume: 1 Pages: 1-1

    • NAID

      10031184509

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synergistic Effect of Proanthocyanidin on Bactericidal Action of the Photolysis of H2O22013

    • Author(s)
      Hiroyo Ikai, Keisuke Nakamura, Taro Kanno, Midori Shirato, Luiz Meirelles, Keiichi Sasaki, Yoshimi Niwano
    • Journal Title

      Bioscience Control

      Volume: in press

    • NAID

      10031202904

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] In Vitro Bactericidal Activity on Photo-irradiated Oxydol Products via Hydroxyl Radical Generation2013

    • Author(s)
      Akira Oyamada, Hiroyo Ikai, Keisuke Nakamura, Eisei Hayashi, Taro Kanno, Keiichi Sasaki, Yoshimi Niwano
    • Journal Title

      Bioscience Control

      Volume: in press

    • NAID

      10031184509

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Photo-irradiation of proanthocyanidin as a new disinfection technique via reactive oxygen species formation2013

    • Author(s)
      Nakamura K, Shirato M, Ikai H, Kanno T, Sasaki K, Kohno M, Niwano Y.
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 3 Pages: e60053-e60053

    • DOI

      10.1371/journal.pone.0060053

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bactericidal Action of Photoirradiated Gallic Acid via Reactive Oxygen Species Formation2012

    • Author(s)
      Nakamura K, Yamada Y, Ikai H, Kanno T, Sasaki K, Niwano Y.
    • Journal Title

      J Agric Food Chem

      Volume: 60 Pages: 10048-10054

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 過酸化水素光分解殺菌技術を応用した新規歯周病治療器の安全性と有効性の検証2014

    • Author(s)
      猪飼紘代,目代貴之,中村圭祐,菅野太郎,庭野吉己.
    • Organizer
      日本防菌防黴学会第41回年次大会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-25 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 活性酸素2014

    • Author(s)
      中村圭祐,菅野太郎,猪飼紘代,庭野吉己.
    • Organizer
      日本防菌防黴学会第41回年次大会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-25 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 過酸化水素光分解殺菌技術における光の波長と過酸化水素濃度の相乗作用2014

    • Author(s)
      倉内美智子,唐木英俊,中村圭祐,菅野太郎,勝田悠介,猪飼紘代,林栄成,佐々木啓一,庭野吉己.
    • Organizer
      日本防菌防黴学会第41回年次大会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-25 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Advantages of new disinfection treatment utilizing photolysis of hydrogen2013

    • Author(s)
      Ikai, H., Odashima, Y., Nakamura, K., Shirato, M., Kanno, T., Sasaki, K., Niwano, Y
    • Organizer
      The Innovative Research for Biosis-Abiosis IntelligentInterface Summer Seminar 2013 in Sendai
    • Place of Presentation
      宮城蔵王
    • Related Report
      2013 Research-status Report
  • [Presentation] 過酸化水素光分解殺菌法の耐性誘導試験2013

    • Author(s)
      猪飼紘代 、中村圭祐、小田島優、白土翠、菅野太郎、庭野吉己
    • Organizer
      日本防菌防黴学会第40回年次大会
    • Place of Presentation
      豊中
    • Related Report
      2013 Research-status Report
  • [Presentation] Bactericidal action of photogenerated singlet oxygen from photosensitizers used in plaque disclosing agents2013

    • Author(s)
      Ishiyama, K., Nakamura, K., Ikai, H., Kanno, T., Sasaki, K., Niwano, Y.
    • Organizer
      The Innovative Research for Biosis-Abiosis IntelligentInterface Summer Seminar 2013 in Sendai
    • Place of Presentation
      宮城蔵王
    • Related Report
      2013 Research-status Report
  • [Presentation] 歯垢染色剤に含まれる各種キサンテン系色素を光感受性物質とした一重項酸素依存性光線力学殺菌療法の比較2013

    • Author(s)
      庭野吉己、石山希里香、中村圭祐、猪飼紘代、菅野太郎、佐々木啓一
    • Organizer
      第23回日本光線力学学会学術講演会
    • Place of Presentation
      旭川
    • Related Report
      2013 Research-status Report
  • [Presentation] 過酸化水素光分解殺菌技術を応用した新規歯周病治療器の開発2013

    • Author(s)
      菅野太郎、中村圭祐、猪飼紘代、庭野吉己、佐々木啓一
    • Organizer
      日本歯周病学会2013春季学術大会(第56回)
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 過酸化水素光分解殺菌法の短時間処理が残存細菌に及ぼす増殖抑制効果2013

    • Author(s)
      小田島優、中村圭祐、猪飼紘代、菅野太郎、佐々木啓一、庭野吉己
    • Organizer
      日本防菌防黴学会第40回年次大会
    • Place of Presentation
      豊中
    • Related Report
      2013 Research-status Report
  • [Presentation] 各種ポリフェノールに対する青色可視光照射で得られる殺菌効果の比較検討2013

    • Author(s)
      中村圭祐、石山希里香、猪飼紘代、菅野太郎、庭野吉己
    • Organizer
      日本防菌防黴学会第40回年次大会
    • Place of Presentation
      豊中
    • Related Report
      2013 Research-status Report
  • [Presentation] 過酸化水素光分解殺菌のカテキン類・生薬併用効果2012

    • Author(s)
      猪飼紘代、白土翠、中村圭祐、菅野太郎、佐々木啓一、庭野吉己
    • Organizer
      日本防菌防黴学会 第39回年次大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 市販オキシドールの光分解殺菌効果2012

    • Author(s)
      小山田晃、猪飼紘代、中村圭祐、菅野太郎、佐々木啓一、庭野吉己
    • Organizer
      日本防菌防黴学会 第39回年次大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] ポリフェノールへの青色可視光照射により生成される活性酸素を応用した新規殺菌技術2012

    • Author(s)
      中村圭祐、山田康友、猪飼紘代、菅野太郎、佐々木啓一、庭野吉己
    • Organizer
      日本防菌防黴学会 第39回年次大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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