Development and clinical evaluation of a new electric toothbrush utilizing disinfection technique based on photolysis of hydrogen peroxide
Project/Area Number |
24593140
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Social dentistry
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Research Institution | Tohoku University |
Principal Investigator |
IKAI Hiroyo 東北大学, 歯学研究科(研究院), 助教 (20431588)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | ヒドロキシルラジカル / 過酸化水素 / 青色可視光 / 殺菌 / 可視光 / 歯ブラシ |
Outline of Final Research Achievements |
In order to apply the bactericidal action of photolysis of hydrogen peroxide to a wide range of civilian goods, I have developed the toothbrush that emits blue visible light from the tip of bristle. A compact size LED was fixed with the head of toothbrush by using a weld technology so that the light could be introduced to the tip of bristle. In addition, the content of hydrogen peroxide contained in commercially available toothpastes and the yield of hydroxyl radical generated by the blue light irradiation of these toothpastes were determined. Based on the determinations, an optimal toothpaste was chosen to be used in a future clinical study. Besides these studies, since it was found that addition of proanthocyanidin, a group of polyphenols, augmented the bactericidal action of photolysis of hydrogen peroxide, it was suggested that a novel toothpaste containing proanthocyanidin could be applicable to the light emitting toothbrush.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Synergistic interaction between wavelength of light and concentration of H2O2 in bactericidal activity of photolysis of H2O2.2015
Author(s)
Toki, T., Nakamura, K., Kurauchi, M., Kanno, T., Katsuda, Y., Ikai, H., Hayashi, E., Egusa, H., Sasaki, K., Niwano, Y.
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Journal Title
Journal of Bioscience and Bioengineering
Volume: 19(3)
Issue: 3
Pages: 1358-1362
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Postantibiotic effect of disinfection treatment by photolysis of hydrogen peroxide.2014
Author(s)
Odashima, Y., Nakamura, K., Ikai, H., Kanno, T., Meirelles, L., Sasaki, K., Niwano, Y.
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Journal Title
Journal of Chemotherapy
Volume: 26(2)
Pages: 92-100
Related Report
Peer Reviewed
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[Journal Article] Postantibiotic effect of disinfection treatment by photolysis of hydrogen peroxide.2014
Author(s)
Odashima, Y., Nakamura, K., Ikai, H., Kanno, T., Meirelles, L., Sasaki, K., Niwano, Y.
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Journal Title
Journal of Chemotherapy
Volume: 26(2):
Issue: 2
Pages: 92-100
DOI
Related Report
Peer Reviewed
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[Journal Article] In vitro evaluation of the risk of inducing bacterial resistance to disinfection treatment with photolysis of hydrogen peroxide2013
Author(s)
Ikai, H., Odashima, Y., Kanno, T., Nakamura, K., Shirato, M., Sasaki, K., Niwano, Y
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Journal Title
PLoS ONE
Volume: 8(11)
Issue: 11
Pages: e81316-e81316
DOI
Related Report
Peer Reviewed
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[Journal Article] Synergistic effect of proanthocyanidin on bactericidal action of photolysis of H2O22013
Author(s)
Ikai, H., Nakamura, K., Kanno, T., Shirato. M., Meirelles, L., Sasaki, K., Niwano, Y.
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Journal Title
Biocontrol Science
Volume: 18(3)
Pages: 137-141
NAID
Related Report
Peer Reviewed
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[Journal Article] In vitro bactericidal activity of photo-irradiated oxydol products via hydroxyl radical generation2013
Author(s)
Oyamada A., Ikai, H., Nakamura, K., Hayashi, E., Kanno, T., Sasaki, K., Niwano, Y.
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Journal Title
Biocontrol Science
Volume: 1
Pages: 1-1
NAID
Related Report
Peer Reviewed
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[Presentation] 活性酸素2014
Author(s)
中村圭祐,菅野太郎,猪飼紘代,庭野吉己.
Organizer
日本防菌防黴学会第41回年次大会
Place of Presentation
東京
Year and Date
2014-09-25 – 2014-09-26
Related Report
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[Presentation] Advantages of new disinfection treatment utilizing photolysis of hydrogen2013
Author(s)
Ikai, H., Odashima, Y., Nakamura, K., Shirato, M., Kanno, T., Sasaki, K., Niwano, Y
Organizer
The Innovative Research for Biosis-Abiosis IntelligentInterface Summer Seminar 2013 in Sendai
Place of Presentation
宮城蔵王
Related Report
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[Presentation] Bactericidal action of photogenerated singlet oxygen from photosensitizers used in plaque disclosing agents2013
Author(s)
Ishiyama, K., Nakamura, K., Ikai, H., Kanno, T., Sasaki, K., Niwano, Y.
Organizer
The Innovative Research for Biosis-Abiosis IntelligentInterface Summer Seminar 2013 in Sendai
Place of Presentation
宮城蔵王
Related Report
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