Investigation of the relationship between aspiration pneumonia onset and aspiration observed by videoendoscopy

• Project/Area Number: 24593146
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Osaka University
• Principal Investigator: Nohara Kanji 大阪大学, 歯学研究科(研究院), 准教授 (20346167)
• Co-Investigator(Kenkyū-buntansha): TAKAI ETSUKO 大阪大学, 歯学部附属病院, 医員 (30532642) ; 若杉 葉子 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (20516281)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 摂食嚥下障害 / 嚥下内視鏡 / 誤嚥 / 誤嚥性肺炎 / 気道線毛輸送機能 / 嚥下障害 / 気道クリアランス / 肺炎球菌 / 気管線毛運動 / サッカリンテスト / 高齢者 / 気道粘液クリアランス

Outline of Final Research Achievements

The subjects comprised 68 dysphagic patients. The presence of respiration-derived fever within 6 months following the videoendoscopy (VE) was assessed, and the VE results and presense of fever during course were compared. There no significant difference in the presence of fever between aspirators and non-aspirators observed by VE. These results suggested that there was a mismatch between the presence of aspiration on the test and the presence of fever.
The mucociliary transport function was evaluated within 54 dysphagic patients. Subject group who had developed fever showed a significantly worse than subject group without fever. These results suggest that a deteriorated mucociliary transport function indicate an increased risk of aspiration pneumonia.

Research Products

• [Journal Article] Cryptochrome-dependent circadian periods in the arcuate nucleus. (2016)
  • Author(s): Uchida H, Nakamura TJ, Takasu NN, Todo T, Sakai T, Nakamura W.
  • Journal Title: Neurosci Lett. Volume: 610 Pages: 123-128
  • DOI: 10.1016/j.neulet.2015.10.071
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 嚥下内視鏡検査における誤嚥の有無と体内の炎症反応についての検討 (2015)
  • Author(s): 若杉葉子，野原幹司，奥野健太郎，深津ひかり，上田菜美，戸原玄，阪井丘芳
  • Journal Title: 日摂食嚥下リハ会誌 Volume: 19 Pages: 11-16
  • NAID: 130007834951
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 終末期の嚥下障害に抗う～薬剤の視点からのアプローチ～ (2015)
  • Author(s): 野原幹司
  • Journal Title: MB Med Reha Volume: 186 Pages: 45-50
  • Peer Reviewed
• [Journal Article] Endoscopic evaluation of food bolus formation and its relationship with the number of chewing cycles (2015)
  • Author(s): Fukatsu H, Nohara K, Kotani Y, Tanaka N, Matsuno K, Sakai T
  • Journal Title: J Oral Rehabil Volume: 42 Issue: 8 Pages: 580-587
  • DOI: 10.1111/joor.12290
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The efficacy of a lingual augmentation prosthesis for swallowing after a glossectomy: A clinical report. (2014)
  • Author(s): Okuno, K., Nohara K., Tanaka N., Sasao Y., Sakai T
  • Journal Title: Journal of Prosthetic Dentistry Volume: 111(4), Issue: 4 Pages: 342-345
  • DOI: 10.1016/j.prosdent.2013.08.011
  • Peer Reviewed
• [Journal Article] Videoendoscopic diagnosis for predicting the response to oral appliance therapy in severe obstructive sleep apnea. (2014)
  • Author(s): Sasao Y., Nohara K., Okuno K., Nakamura Y., Sakai T
  • Journal Title: Sleep and Breathing Volume: 18(4) Issue: 4 Pages: 809-815
  • DOI: 10.1007/s11325-014-0947-3
  • NAID: 130005405106
  • Peer Reviewed
• [Journal Article] Effects of the bolusvolume on hyoid movements in normal individuals. (2013)
  • Author(s): Ueda, N., Nohara, K., Kotani, Y., Tanaka, N., Okuno, K., Sakai, T.
  • Journal Title: Journal of Oral Rehabilitation Volume: 40(7) Issue: 7 Pages: 491-499
  • DOI: 10.1111/joor.12060
  • Peer Reviewed
• [Journal Article] Swallowing frequency in elderly people during daily life. (2013)
  • Author(s): Tanaka, N., Nohara, K., Kotani, Y., Matsumura, M., Sakai, T.
  • Journal Title: Journal of Oral Rehabilitation Volume: 40(10) Issue: 10 Pages: 744-750
  • DOI: 10.1111/joor.12085
  • NAID: 130007843698
  • Peer Reviewed
• [Journal Article] Effects of the Bolus Volume on Hyoid Movements in Normal Individuals (2013)
  • Author(s): Ueda N, Nohara K, et al
  • Journal Title: J Oral Rehabil Volume: 40
  • NAID: 130007837796
  • Peer Reviewed
• [Journal Article] Development of a swallowing frequency meter using a laryngeal microphone (2012)
  • Author(s): Tanaka N, Nohara K, Okuno K, Kotani Y, Okazaki H, Matsumura M, Sakai T
  • Journal Title: Journal of Oral Rehabilitation Volume: (印刷中) Issue: 6 Pages: 411-420
  • DOI: 10.1111/j.1365-2842.2012.02293.x
  • Peer Reviewed
• [Journal Article] 認知症の病型別（原因疾患別）の摂食・嚥下障害の特徴とアプローチ～血管性認知症 (2012)
  • Author(s): 野原幹司
  • Journal Title: 地域リハ Volume: 7 Pages: 458-462
• [Presentation] 多職種で取り組む摂食嚥下リハビリテーション (2015)
  • Author(s): 野原幹司
  • Organizer: 第8回備後地域リハビリテーション研究会
  • Place of Presentation: 広島県立ふくやま産業交流会館（広島県・福山市）
  • Year and Date: 2015-11-06
  • Invited
• [Presentation] 多職種で取り組む誤嚥性肺炎の予防戦略 (2015)
  • Author(s): 野原幹司
  • Organizer: 第20回岡南胸部疾患フォーラム学術研修会
  • Place of Presentation: ホテルグランヴィア岡山（岡山県・岡山市）
  • Year and Date: 2015-10-17
  • Invited
• [Presentation] 増粘剤の濃度の違いが粘液線毛輸送に及ぼす影響 (2015)
  • Author(s): 野原幹司，相えりか，深津ひかり，田中信和，阪井丘芳
  • Organizer: 第25回日本呼吸ケア・リハビリテーション学会学術集会
  • Place of Presentation: 東京ベイ舞浜ホテル（千葉県・浦安市）
  • Year and Date: 2015-10-15
• [Presentation] Effects of application of thickening agent on mucocilliary transport time (2015)
  • Author(s): Nohara K, Ai E, Fukatsu H, Tanaka N, Okuno K, Sakai T
  • Organizer: The 5th ESSD Congress
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2015-10-01
  • Int'l Joint Research
• [Presentation] 認知症の摂食嚥下障害 (2014)
  • Author(s): 野原幹司
  • Organizer: 第４回認知症の人の食支援研究会
  • Place of Presentation: パピヨン24ガスホール（福岡県福岡市）
  • Year and Date: 2014-12-21
  • Invited
• [Presentation] Relationship between airway clearance function and aspiration pneumonia in geriatric nursing home residents (2014)
  • Author(s): Nohara K, Kaneko N, Uchida Y, Tanaka N, Sakai T
  • Organizer: The 4th ESSD Congress
  • Place of Presentation: Brussels (Belgium)
  • Year and Date: 2014-10-23 – 2014-10-25
• [Presentation] 内視鏡を用いた粘膜線毛輸送機能の評価法の確立～サッカリンテストとの比較～ (2014)
  • Author(s): 深津ひかり，野原幹司，阪井丘芳
  • Organizer: 第20回日本摂食嚥下リハビリテーション学会学術大会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2014-09-06 – 2014-09-07
• [Presentation] 病態別対応 認知症の嚥下リハ (2014)
  • Author(s): 野原幹司
  • Organizer: 第２１回山口摂食嚥下研究会
  • Place of Presentation: ANAクラウンプラザホテル宇部（山口県宇部市）
  • Year and Date: 2014-06-15
  • Invited
• [Presentation] 口から全身の老化を考える－抗加齢歯科医学の最前線－ 口から誤嚥性肺炎に抗う～侵襲と抵抗のバランスを考慮した多面的アプローチ～ (2014)
  • Author(s): 野原幹司
  • Organizer: 第14回日本抗加齢医学会総会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2014-06-06 – 2014-06-07
• [Presentation] Effect of mucociliary transport function on incidence of aspiration pneumonia in elderly aspirators (2014)
  • Author(s): Kaneko N, Nohara K, Tanaka N, Ueda N, Mitsuyama M, Sakai T
  • Organizer: DRS
  • Place of Presentation: Nashville
• [Presentation] Videofluorographic study of velar velocity during speech and swallowing (2013)
  • Author(s): Nohara K, Takai E, Ueda N, Sakai T
  • Organizer: ESSD congress
  • Place of Presentation: Malmo
• [Presentation] 誤嚥性呼吸器疾患発症における気道粘液線毛輸送機能の影響～サッカリンテストを用いた検討 (2013)
  • Author(s): 野原幹司，金子信子，上田菜美，沖侑大郎，石川朗，阪井丘芳
  • Organizer: 第23回日本呼吸ケア・リハビリテーションプログラム学会学術集会
  • Place of Presentation: 東京
• [Presentation] 内視鏡を用いて評価した高齢者の食塊形成機能～喉頭侵入の有無による検討～ (2012)
  • Author(s): 松野頌平，野原幹司，深津ひかり，小谷泰子，阪井丘芳
  • Organizer: 第17回 第18回共催 日本摂食・嚥下リハビリテーション学会
  • Place of Presentation: 札幌
• [Presentation] 内視鏡を用いて評価した高齢者の食塊形成機能～若年者との比較および義歯の有無による検討～ (2012)
  • Author(s): 深津ひかり, 野原幹司, 松野頌平, 阪井丘芳
  • Organizer: 第17回 第18回共催 日本摂食・嚥下リハビリテーション学会
  • Place of Presentation: 札幌
• [Presentation] 食医のススメ－歯科が行う摂食・嚥下リハビリテーション
  • Author(s): 野原幹司
  • Organizer: 第22回日本歯科医学会総会
  • Place of Presentation: 大阪
  • Invited
• [Book] Ⅱ老年歯科医学の実際 ４摂食嚥下障害 ３－口腔がん手術後．老年歯科医学 (2015)
  • Author(s): 野原幹司
  • Total Pages: 3
  • Publisher: 医歯薬出版
• [Book] 認知症で摂食嚥下障害がある患者の口腔ケアにおいて注意すべき点やポイントについて教えてください 続５疾病の口腔ケア (2015)
  • Author(s): 野原幹司
  • Total Pages: 4
  • Publisher: 医歯薬出版
• [Book] 認知症高齢者への食支援と口腔ケア (2014)
  • Author(s): 野原幹司
  • Total Pages: 15
  • Publisher: ワールドプランニング
• [Book] 口腔ケア 嚥下機能評価 (2014)
  • Author(s): 野原幹司
  • Total Pages: 3
  • Publisher: PEGドクターズネットワーク
• [Book] 摂食・嚥下障害マネジメント キュアからケアへ (2014)
  • Author(s): 野原幹司
  • Publisher: ケアネット