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Obesity, chronic inflammation and gene-environment interaction: common pathological basis of oral and metabolic diseases

Research Project

Project/Area Number 24593148
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionOsaka University

Principal Investigator

OJIMA MIKI  大阪大学, 歯学研究科(研究院), 助教 (20263303)

Co-Investigator(Kenkyū-buntansha) KUBONIWA Masae  大阪大学, 歯学部附属病院, 講師 (00303983)
NAGATA Hideki  大阪大学, 大学院歯学研究科, 准教授 (50260641)
Co-Investigator(Renkei-kenkyūsha) HANIOKA Takashi  福岡歯科大学, 口腔歯学部, 教授 (00144501)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords歯学 / 肥満 / メタボリックシンドローム / 齲蝕 / 歯周病 / 歯の補綴 / 食習慣 / 口腔細菌叢 / 歯周病菌 / 脂質異常 / 高血圧 / 食生活
Outline of Final Research Achievements

Although increasing epidemiological evidence linking poor oral health and systemic conditions has been presented, underlying mechanisms in the relationship remain unclear. The present study aimed to construct a dental-medical linkage database of health checkup records, and to evaluate the relationship of dental caries, periodontal condition, number of teeth and prosthetic condition with metabolism biomarkers and medical findings using multivariate logistic regression models. We found several oral-systemic relationships: prosthetic status and hypertension, and medical finding in gastrointestinal legions, decayed teeth and metabolic syndrome, and obesity, periodontal condition and fatty liver in non-drinkers, polymicrobial infection with major periodontal pathogens and serum lipid profile.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (28 results)

All 2015 2014 2013 2012 Other

All Journal Article (9 results) (of which Peer Reviewed: 8 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (16 results) (of which Invited: 3 results) Book (3 results)

  • [Journal Article] Relationship Between Decayed Teeth and Metabolic Syndrome: Data From 4716 Middle-Aged Male Japanese Employees2015

    • Author(s)
      Ojima M, Amano A, Kurata S
    • Journal Title

      Journal of Epidemiology

      Volume: 25 Issue: 3 Pages: 204-211

    • DOI

      10.2188/jea.JE20140132

    • NAID

      130004851898

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Proteomic and Transcriptional Analysis of Interaction between Oral Microbiota Porphyromonas gingivalis and Streptococcus oralis.2015

    • Author(s)
      Maeda K, Nagata H, Ojima M, Amano A
    • Journal Title

      Journal of Proteome Research

      Volume: 14 Issue: 1 Pages: 82-94

    • DOI

      10.1021/pr500848e

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Education on tobacco use interventions forundergraduate dental students2015

    • Author(s)
      Hanioka T, Ojima M, Kawaguchi Y, Hirata Y, Ogara H, Hinode D, Hanada N, Inoshita E
    • Journal Title

      Japanese Dental Science Review

      Volume: 51 Issue: 3 Pages: 1-10

    • DOI

      10.1016/j.jdsr.2015.03.003

    • NAID

      50009780245

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Daily smoking may independently predict caries development in adults2014

    • Author(s)
      Hanioka T, Ojima M, Tanaka K
    • Journal Title

      J Evid Based Dent Pract

      Volume: 14 Issue: 3 Pages: 151-153

    • DOI

      10.1016/j.jebdp.2014.07.005

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tobacco interventions by dentists and dental hygienists2013

    • Author(s)
      Hanioka T, Ojima M, Kawaguchi Y, Hirata Y, Ogawa H, Mochizuki Y
    • Journal Title

      Japanese Dental Science Review

      Volume: 49 Issue: 1 Pages: 47-56

    • DOI

      10.1016/j.jdsr.2012.11.005

    • NAID

      10031201723

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of various effects of smoking in the mouth on motivating dental patients to quit smoking2013

    • Author(s)
      Hanioka T, Tsutsui A, Yamamoto M, Haresaku S, Shimada K, Watanabe T, Matsuo T, Ojima M
    • Journal Title

      International Journal of Statistics in Medical Research

      Volume: 2 Issue: 1 Pages: 40-46

    • DOI

      10.6000/1929-6029.2013.02.01.05

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Smoking increases risk of tooth loss: A meta-analysis of the literature2013

    • Author(s)
      Sato F, Sawamura M, Ojima M, Tanaka K, Hanioka T, Tanaka H, Matsuo K*
    • Journal Title

      World Journal of Meta-Analysis

      Volume: 26 Issue: 1 Pages: 16-26

    • DOI

      10.13105/wjma.v1.i1.16

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The role of tobacco use on dental care and oral disease severity within community dental clinics in Japan2013

    • Author(s)
      Ojima M, Hanioka T, Shimada K, Haresaku S, Yamamoto M, Tanaka K
    • Journal Title

      Tobacco Induced Diseases

      Volume: 11 Issue: 1 Pages: 13-13

    • DOI

      10.1186/1617-9625-11-13

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 特別企画 全身の健康へのアプローチ 歯肉溝滲出液検査の利用 ④予防歯科診療への応用2012

    • Author(s)
      小島美樹, 関根伸一, 天野敦雄
    • Journal Title

      歯界展望

      Volume: 119 Pages: 900-901

    • Related Report
      2012 Research-status Report
  • [Presentation] 歯科でのタバコ対策の現状と課題2015

    • Author(s)
      小島美樹
    • Organizer
      第64回日本口腔衛生学会・総会
    • Place of Presentation
      つくば市
    • Year and Date
      2015-05-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Relationship Between Decayed Teeth and Metabolic Syndrome: Data From 4716 Middle-Aged Male Japanese Employees2015

    • Author(s)
      小島美樹
    • Organizer
      第64回日本口腔衛生学会・総会
    • Place of Presentation
      つくば市
    • Year and Date
      2015-05-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 中年期における肥満と齲蝕─事業所健診データを用いた後向きコホート調査─2015

    • Author(s)
      小島美樹、天野敦雄、倉田 秀
    • Organizer
      第64回日本口腔衛生学会・総会
    • Place of Presentation
      つくば市
    • Year and Date
      2015-05-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Relationship between periodontal condition and fatty liver in non-drinkers.2014

    • Author(s)
      Ojima M, Amano A, Kurata S
    • Organizer
      第62回国際歯科研究学会日本部会総会・学術大会
    • Place of Presentation
      大阪市
    • Year and Date
      2014-12-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] NCDs歯科疾患共通リスク要因介入のRE-AIMによる公衆衛生卒前教育モデル2014

    • Author(s)
      埴岡 隆,小島美樹,青山 旬,井下英二,尾崎哲則,川口陽子,田中景子
    • Organizer
      第73回日本公衆衛生学会総会
    • Place of Presentation
      宇都宮市
    • Year and Date
      2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Decayed teeth and metabolic syndrome in early middle-aged Japanese2014

    • Author(s)
      Ojima M, Amano A, Kurata S
    • Organizer
      11th International Conference of Asian Academy of Preventive Dentistry
    • Place of Presentation
      Beijing
    • Year and Date
      2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 歯周ポケット内細菌叢の複雑化が脂質プロフィールに与える影響2014

    • Author(s)
      清原宏之,小島美樹,小野高裕,泉井秀介,関根伸一,永田英樹,天野敦雄
    • Organizer
      第63回日本口腔衛生学会・総会
    • Place of Presentation
      熊本市
    • Year and Date
      2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 歯の欠損の治療放置は高血圧管理に影響を与えるか?2013

    • Author(s)
      小島美樹、天野敦雄、倉田 秀
    • Organizer
      第62日本口腔衛生学会・総会
    • Place of Presentation
      松本市
    • Related Report
      2012 Research-status Report
  • [Presentation] 喫煙による超過補綴の歯科医療費と歯科禁煙診療による削減効果の推計2012

    • Author(s)
      小島美樹, 埴岡隆, 青山旬, 平田幸夫, 尾崎哲則, 天野敦雄
    • Organizer
      第61回日本口腔衛生学会・総会
    • Place of Presentation
      横須賀市
    • Related Report
      2012 Research-status Report
  • [Presentation] 疾患リスクの予測を目的とした歯科外来で行う検体検査~遺伝子と細菌検査を中心として~2012

    • Author(s)
      小島美樹
    • Organizer
      藤井寺市歯科医師会学術講演会
    • Place of Presentation
      藤井寺市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Association of prosthetic status with dietary pattern and systemic condition2012

    • Author(s)
      Ojima M, Kurata S, Amano A
    • Organizer
      60th Annual Meeting of JADR
    • Place of Presentation
      Niigata
    • Related Report
      2012 Research-status Report
  • [Presentation] Characteristic of dental care received by smokers in Japan

    • Author(s)
      Ojima M
    • Organizer
      Symposium 3 (Smoking and oral health), The 10th Asia Pacific Conference on Tobacco or Health
    • Place of Presentation
      Makuhari Messe (Chiba)
    • Related Report
      2013 Research-status Report
  • [Presentation] タバコと口腔バイオフィルムの関連性の知見を禁煙推進にどのように活かすか?

    • Author(s)
      小島美樹
    • Organizer
      第62回日本口腔衛生学会・総会
    • Place of Presentation
      キッセイ分科ホール(松本)
    • Related Report
      2013 Research-status Report
  • [Presentation] 歯の欠損の治療放置は高血圧管理に影響を与えるか?

    • Author(s)
      小島美樹、天野敦雄、倉田 秀
    • Organizer
      第62回日本口腔衛生学会・総会
    • Place of Presentation
      キッセイ分科ホール(松本)
    • Related Report
      2013 Research-status Report
  • [Presentation] 健診情報を用いた歯の欠損補綴の必要性と消化器健診所見との関連解析

    • Author(s)
      小島美樹
    • Organizer
      第72回日本公衆衛生学会総会
    • Place of Presentation
      三重県総合文化センター(津市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 歯周ポケット内細菌叢の複雑化が脂質プロフィールに与える影響: 吹田研究

    • Author(s)
      清原宏之,小島美樹,小野高裕,泉井秀介,関根伸一,永田英樹,天野敦雄
    • Organizer
      第63回日本口腔衛生学会・総会
    • Place of Presentation
      熊本市民会館 崇城大学ホール(熊本市)
    • Related Report
      2013 Research-status Report
  • [Book] 歯科衛生士のための禁煙支援ガイドブック(尾崎哲則・埴岡 隆編)2013

    • Author(s)
      小島美樹
    • Total Pages
      108
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2013 Research-status Report
  • [Book] 特定健康診査・特定保健指導における禁煙支援から始めるたばこ対策(大井田 隆・中村正和・尾崎哲則編)2013

    • Author(s)
      埴岡 隆,小島美樹
    • Total Pages
      526
    • Publisher
      日本公衆衛生協会
    • Related Report
      2013 Research-status Report
  • [Book] 歯科衛生士のための禁煙支援ガイドブック2013

    • Author(s)
      小島美樹
    • Total Pages
      108
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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