Anti-aging effects of ubiquinol on oral tissues

• Project/Area Number: 24593153
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Okayama University
• Principal Investigator: TOMOFUJI Takaaki 岡山大学, 大学病院, 講師 (80335629)
• Co-Investigator(Kenkyū-buntansha): MORITA Manabu 岡山大学, 医歯(薬)学総合研究科, 教授 (40157904) ; EKUNI Daisuke 岡山大学, 大学病院, 講師 (70346443) ; AZUMA Tetsuji 岡山大学, 医歯(薬)学総合研究科, 助教 (80432649) ; 遠藤 康正 岡山大学, 大学病院, その他 (50580213)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 抗加齢 / ユビキノール / 還元型コエンザイムQ10 / コエンザイムQ10 / 歯周組織 / 酸化ストレス

Outline of Final Research Achievements

Oxidative stress is associated with aging of the periodontal tissue. The anti-oxidative effects of a reduced form of co-enzyme Q10 (ubiquinol) may affect periodontal tissue aging. We examined the effects of topically applied ubiquinol on periodontal tissue aging in a rat model. Male Fischer 344 rats received topically applied ointment with or without 1% ubiquinol on the gingival surface until they reached 6 mos of age. Ubiquinol decreased oxidative DNA damage and tartrate-resistant acid-phosphatase-positive osteoclasts in the periodontal tissue as compared with the control. The results indicate that topical application of ubiquinol could suppress age-related osteoclast differentiation by inhibiting oxidative stress.

Research Products

• [Journal Article] Application of coenzyme Q10 for accelerating wound healing after tooth extraction (2014)
  • Author(s): Yoneda T, Tomofuji T, Kawabata Y, Ekuni D, Azuma T, Kataoka K, Kunitomo M, Morita M
  • Journal Title: Nutrients Volume: 6 Issue: 12 Pages: 5756-5769
  • DOI: 10.3390/nu6125756
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Anti-aging effects of dentifrices containing anti-oxidative, anti-inflammatory, and anti-bacterial agents (Tomarina®) on gingival collagen degradation in rats (2014)
  • Author(s): Irie K, Tomofuji T, Ekuni D, Endo Y, Kasuyama K, Azuma T, Tamaki N, Yoneda T, Morita M
  • Journal Title: Arch Oral Biol Volume: 59 Pages: 60-65
  • Peer Reviewed
• [Journal Article] Anti-aging effects of coenzyme Q10 on periodontal tissue. (2013)
  • Author(s): Yoneda T, Tomofuji T, Ekuni D, Azuma T, Endo Y, Kasuyama K, Machida T, Morita M.
  • Journal Title: Journal of Dental Research Volume: ９２ Issue: 8 Pages: 735-739
  • DOI: 10.1177/0022034513490959
  • Peer Reviewed
• [Presentation] 還元型コエンザイムQ10の抜歯窩創傷治癒への効果の検討 (2014)
  • Author(s): 米田俊樹、友藤孝明、川端勇也、江國大輔、東 哲司、片岡広太、國友宗義、森田 学
  • Organizer: 第25回近畿・中国・四国口腔衛生学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-05