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Anti-aging effects of ubiquinol on oral tissues

Research Project

Project/Area Number 24593153
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionOkayama University

Principal Investigator

TOMOFUJI Takaaki  岡山大学, 大学病院, 講師 (80335629)

Co-Investigator(Kenkyū-buntansha) MORITA Manabu  岡山大学, 医歯(薬)学総合研究科, 教授 (40157904)
EKUNI Daisuke  岡山大学, 大学病院, 講師 (70346443)
AZUMA Tetsuji  岡山大学, 医歯(薬)学総合研究科, 助教 (80432649)
遠藤 康正  岡山大学, 大学病院, その他 (50580213)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords抗加齢 / ユビキノール / 還元型コエンザイムQ10 / コエンザイムQ10 / 歯周組織 / 酸化ストレス
Outline of Final Research Achievements

Oxidative stress is associated with aging of the periodontal tissue. The anti-oxidative effects of a reduced form of co-enzyme Q10 (ubiquinol) may affect periodontal tissue aging. We examined the effects of topically applied ubiquinol on periodontal tissue aging in a rat model. Male Fischer 344 rats received topically applied ointment with or without 1% ubiquinol on the gingival surface until they reached 6 mos of age. Ubiquinol decreased oxidative DNA damage and tartrate-resistant acid-phosphatase-positive osteoclasts in the periodontal tissue as compared with the control. The results indicate that topical application of ubiquinol could suppress age-related osteoclast differentiation by inhibiting oxidative stress.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Application of coenzyme Q10 for accelerating wound healing after tooth extraction2014

    • Author(s)
      Yoneda T, Tomofuji T, Kawabata Y, Ekuni D, Azuma T, Kataoka K, Kunitomo M, Morita M
    • Journal Title

      Nutrients

      Volume: 6 Issue: 12 Pages: 5756-5769

    • DOI

      10.3390/nu6125756

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Anti-aging effects of dentifrices containing anti-oxidative, anti-inflammatory, and anti-bacterial agents (Tomarina®) on gingival collagen degradation in rats2014

    • Author(s)
      Irie K, Tomofuji T, Ekuni D, Endo Y, Kasuyama K, Azuma T, Tamaki N, Yoneda T, Morita M
    • Journal Title

      Arch Oral Biol

      Volume: 59 Pages: 60-65

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-aging effects of coenzyme Q10 on periodontal tissue.2013

    • Author(s)
      Yoneda T, Tomofuji T, Ekuni D, Azuma T, Endo Y, Kasuyama K, Machida T, Morita M.
    • Journal Title

      Journal of Dental Research

      Volume: 92 Issue: 8 Pages: 735-739

    • DOI

      10.1177/0022034513490959

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 還元型コエンザイムQ10の抜歯窩創傷治癒への効果の検討2014

    • Author(s)
      米田俊樹、友藤孝明、川端勇也、江國大輔、東 哲司、片岡広太、國友宗義、森田 学
    • Organizer
      第25回近畿・中国・四国口腔衛生学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-05
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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