Study on early detection and prevention of oral cancer for HIV infected people

• Project/Area Number: 24593162
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Yokohama City University
• Principal Investigator: CHIKUMARU Hiroshi 横浜市立大学, 医学部, 助教 (80217231)
• Co-Investigator(Kenkyū-buntansha): UEDA Atsuhisa 横浜市立大学, 医学部, 准教授 (60295483) ; MITSUDO Kenji 横浜市立大学, 医学部, 准教授 (70303641)
• Research Collaborator: OKUBO Makiko ; SHIRAI Akira ; ISHIKAWA Yoshimi ; OTA Yoshihide
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 口腔癌 / スクリーニング / HIV / 前癌病変 / HIV感染者 / 口腔がんスクリーニング / 口腔前癌病変 / 非AIDS指標悪性腫瘍 / がんスクリーニング / 癌

Outline of Final Research Achievements

We have evaluated the risk of developing precancerous lesion of the oral cavity in HIV infected persons in Japan by a case control study.We have performed oral cancer screening in HIV infected persons. The screenings was performed on 82 HIV patients. The protocol is same to this in Oral Cancer Screening Project in Kanagawa prefecture (OCSPK). The content of data was extracted from these screenings, analyzed and compared with data from OCSPK. Ten patients were female sex, others were male, and the median age was 52 years old. Forty point two percent of patients had a smoking habit, 14.6 % had an alcohol habit, 30.5 % have a family cancer history. Although there was no patient complicated with oral cancer, 14.9% were diagnosed as having precancerous lesion. Although oral precancerous lesion was frequently seen in HIV patient, the relative risk is almost same to smoking. Therefore HIV patients should be encouraged oral cancer screening and cessation of smoking.

Research Products

• [Presentation] HIV感染者の口腔前癌病変発症リスクの検討 (2014)
  • Author(s): 筑丸 寛, 大久保牧子, 上田敦久, 白井 輝, 竹林早苗, 松山奈央, 石川好美, 金子明寛, 太田嘉英, 石ヶ坪良明, 藤内 祝
  • Organizer: 第28回日本エイズ学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪府）
  • Year and Date: 2014-12-04