| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Outline of Final Research Achievements |
It is widely known that the periodontal pathogenic bacterium Porphyromonas gingivalis (P. gingivalis) has the ability to directly invade to the mucosal epithelial cells. In recent years, several studies indicate that this bacterium invades in the lesion tissue of gingiva in periodontitis patients, indeed. However, it is not completely clarified the pathogenic mechanism of P. gingivalis intracellular invasion. We will investigate any kind of biological activity the invasion of P. gingivalis is able to induce. Moreover, since it is difficult to remove P. gingivalis invaded in the cells in detail by using the general antibiotics, we will also consider any drugs that can remove the intracellularly invaded bacterium or that prevent the intracellular invasion of the pathogen.
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