| Project/Area Number |
24593166
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KAMIYA Shigeru 杏林大学医学部, 感染症学教室, 教授 (10177587)
OSAKI Takako 杏林大学医学部, 感染症学教室, 准教授 (90255406)
HANAWA Tomoko 杏林大学医学部, 感染症学教室, 講師 (80255405)
KURATA Satoshi 杏林大学医学部, 感染症学教室, 助教 (00383670)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ヘリコバクター・ピロリ |
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| Outline of Final Research Achievements |
Helicobacter pylori is one of the most common causes of bacterial infection in humans. H. pylori is transmitted via the oral cavity. The oral cavity is colonized by a variety of microorganisms. The aim of this study is to characterize the mutual interaction between H. pylori and oral bacteria in vitro. Some of oral bacteria such as Streptococcus mutans were strongly aggregated with H. pylori. In this aggregation state, the expression of urease, which is one of colonization factor of H. pylori, was higher than that in H. pylori single-culture. In addition, oral inoculation by the H. pylori and S. mutans co-culture exhibited an increased initial infection rate relative to that by the H. pylori single culture. Taken together, these results suggest that coexistence of oral bacteria such as S. mutans might enhance the colonization of H. pylori in the human gastrointestinal tract.
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