| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Outline of Final Research Achievements |
For improvement of human oral health environment and disease prevention without using medicine and chemicals, a basic research to create the "synbiotics" which is fusion of probiotics and prebiothics, and "biogenics" using active ingredient was performed.
Although lactobacilli could grow with three kinds of sugar, dental cariogenic bacteria and oral candidiagenic fungus could not be multiplied; therefore it was indicated that those were desirable as prebiotics. Five strains were selected as probiotics candidates, which suppressed the cariogenic bacteria, periodontal bacteria, and oral candidiagenic fungus in common. Active ingredients against the periodontal bacillus were refined from the culture supernatant of two lactobacilli strains, and a possibility was suggested that one major effective component was lactic acid and the other was a low molecular weight substance which did not depend on lactic acid.
|
