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Development of ozone gel for medicine on preventing and/or treating periodontal disease

Research Project

Project/Area Number 24593179
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionOsaka Dental University

Principal Investigator

OH Hourei  大阪歯科大学, 歯学部, 教授 (20213613)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsオゾン ジェル / 歯周疾患 / 歯周病治療薬 / 抗炎症作用 / 止血作用 / 口臭抑制薬 / 細胞増殖能 / オゾン / オゾンジェル / 歯周病 / 歯周組織再生療法 / 再生治療 / 歯周治療薬 / 再生医療
Outline of Final Research Achievements

Currently, ozone is being discussed in dentistry as a possible alternative oral antiseptic agent. We have developed the ozone gel which is a glycerin solution containing ozone. The advantages of ozone gel include its long sterilization effect and a lack of an unpleasant smell, as well as the fact that it does not induce resistance in bacteria. In this study, we evaluated the safety of ozone gel in the treatment of oral mucosa irritation as well as its effects on hemostasis and antimicrobial effects. we revealed that ozone gel was very mild to the oral mucosa. The hemostatic ability of ozone gel was almost equal to the Bosmin solution and Liquid Thrombin. The instantaneous antibacterial effect of ozone gel was observed.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (18 results)

All 2015 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (12 results) Book (2 results)

  • [Journal Article] Evalution of Oral Mucosa Irritation produced by Ozone Gel2015

    • Author(s)
      Fukui T, Masuno K, Makita Y,Fujiwara S, Shiota G, Imamura Y, Shiba A, Wang P
    • Journal Title

      J Hard Tissue Biol

      Volume: 24 Pages: 104-106

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] オゾン水、オゾンジェルによる止血作用の薬理学的考察2014

    • Author(s)
      王 宝禮
    • Journal Title

      オゾン医療

      Volume: 3 Pages: 8-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Local Hemostatic Effect of Aqueous Ozone in Cutting Wound Surface2014

    • Author(s)
      Sakai D, Makita Y, Masuno K, Fujiwara S, Okazaki J, Wang P
    • Journal Title

      J Hard Tissue Biol

      Volume: 23 Pages: 245-248

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 歯科医療へのオゾン療法2014

    • Author(s)
      王宝禮
    • Journal Title

      OZONE NEWS

      Volume: 90 Pages: 14-19

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] オゾンによる口臭除去効果2014

    • Author(s)
      王 宝禮, 芝 燁彦
    • Organizer
      第5回オゾン医療研究会
    • Place of Presentation
      文京学院大学(東京都,文京区)
    • Year and Date
      2014-12-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] オゾン水、オゾンジェルの歯科医療における生理活性の探求2014

    • Author(s)
      王 宝禮, 廣田 健,瀧沢 努,村川 昇,松永省三,五味 章, 益野一哉
    • Organizer
      第32回日本歯科東洋医学会
    • Place of Presentation
      岐阜じゅうろくプラザ(岐阜県,岐阜市)
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] インプラント治療におけるオゾン局所止血作用効果の解明2014

    • Author(s)
      益野一哉 赤木 誉, 福井達也,王 宝禮
    • Organizer
      第44回日本口腔インプラント学会
    • Place of Presentation
      東京国際フォーラム(東京都,千代田区)
    • Year and Date
      2014-09-14 – 2014-09-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 院内感染や耐性菌を考えた抗菌療法とは?2014

    • Author(s)
      王 宝禮
    • Organizer
      日本歯科保存学会春季学術大会(第140回)
    • Place of Presentation
      滋賀県芸術琵琶湖ホール(滋賀県,大津市)
    • Year and Date
      2014-06-19 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] オゾンの局所止血効果2014

    • Author(s)
      益野一哉, 佐藤哲夫, 倉 知子,王 宝禮
    • Organizer
      第57回春季日本歯周病学会学術大会
    • Place of Presentation
      長良川国際会議場(岐阜県,岐阜市))
    • Year and Date
      2014-05-22 – 2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] インプラント周囲炎へのベストな抗菌薬物療法ー抗生物質&オゾンー2013

    • Author(s)
      王宝禮
    • Organizer
      UP2013 EXTREAM MEETING
    • Place of Presentation
      東京プリンスホテル(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] オゾンを活用した日常歯科臨床および院内感染予防対策2013

    • Author(s)
      廣田健、王宝禮、中室克彦、村上弘
    • Organizer
      第17回日本統合医療学会
    • Place of Presentation
      日本赤十字看護大学(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] 日常歯科臨床と院内感染対策へのオゾンの有用性2012

    • Author(s)
      王宝禮
    • Organizer
      第30回日本歯科東洋医学会学術大会
    • Place of Presentation
      福岡県福岡市
    • Related Report
      2012 Research-status Report
  • [Presentation] オゾンの歯周病治療への応用2012

    • Author(s)
      王宝禮
    • Organizer
      第55回日本歯周病学会秋季学術大会
    • Place of Presentation
      茨城県つくば市
    • Related Report
      2012 Research-status Report
  • [Presentation] オゾンジェルの歯周病菌への影響2012

    • Author(s)
      王宝禮
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      福島県郡山市
    • Related Report
      2012 Research-status Report
  • [Presentation] オゾンの止血作用の解明

    • Author(s)
      王宝禮
    • Organizer
      第5回オゾン医療研究会
    • Place of Presentation
      文京大学(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] オゾン水を用いた歯内療法

    • Author(s)
      廣田健、王 宝禮、塩田剛太郎
    • Organizer
      日本医療・環境オゾン学会第18回研究講演会
    • Place of Presentation
      日本薬学会館長井記念ホール(東京都)
    • Related Report
      2013 Research-status Report
  • [Book] 獣医療にオゾンを活かす場合2015

    • Author(s)
      鷲巣 誠, 三浦敏明,中室克彦、嵯峨井勝,清水無空,岡本芳晴, 上原愛童, 柴田真治,橋本雄一郎,小畑浩身,柳原唯雄,王 宝禮,伊藤宏泰
    • Publisher
      ファームプレス MVM編集部
    • Related Report
      2014 Annual Research Report
  • [Book] 薬 12/132012

    • Author(s)
      王 宝禮
    • Total Pages
      223
    • Publisher
      クインテッセンス出版株式会社
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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