• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Establishing Suitable Nursing Care from a Pharmacological Approach for Skin Disorders Due to Obesity

Research Project

Project/Area Number 24593252
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Fundamental nursing
Research InstitutionYokohama City University

Principal Investigator

AKASE Tomoko  横浜市立大学, 医学部, 教授 (50276630)

Co-Investigator(Kenkyū-buntansha) SANADA Hiromi  東京大学, 医学系研究科, 教授 (50143920)
NAGASE Takashi  東京大学, 医学系研究科, 特任講師 (00359613)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords肥満 / 皮膚障害 / 皮下脂肪 / 与薬 / 皮膚 / 薬理学 / スキンケア / 看護学
Outline of Final Research Achievements

This study aims to establish preventative measures and suitable nursing care for inflammation skin disorders that many obese people are thought to be at risk of. Animal experiments showed that a systemic approach through Kaempferia parviflora (KP), which has anti-oxidizing and anti-obesity effects, was effective. The combined effects of KP also suggested that increase in body weight and weakening of the skin could be inhibited and a three-dimensional system structure could be maintained. Furthermore, a weight loss treatment that lasted for a period of eight weeks showed a decrease in signs of inflammation from subcutaneous fat and serpiginous nature of collagen of the dermis. We should be able to effectively prevent skin disorders due to obesity in the future through dietary management that includes KP and the intake of supplements.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (24 results)

All 2016 2015 2014 2013 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (18 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] 2型糖尿病患者の皮膚の加齢性変化に対する肥満重症度の影響2016

    • Author(s)
      豊崎有紀子、相羽実咲、伊吹愛、赤瀬智子
    • Journal Title

      横浜看護学雑誌

      Volume: 9(1) Pages: 19-24

    • NAID

      120005892551

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 看護学におけるトランスレーショナルリサーチー肥満の皮膚障害に対するスキンケア方法の確立を目指してー2015

    • Author(s)
      赤瀬智子
    • Journal Title

      Co-Medical研究会雑誌

      Volume: 3(1) Pages: 13-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Epidermal barrier function in the Skin of Japanese Obese Women: a Pilot Study.2015

    • Author(s)
      Ibuki A, Inoue A, Matsumoto Y, Horie Y, Akase T
    • Journal Title

      Yokohama Journal of Nursing

      Volume: 8(1) Pages: 28-32

    • NAID

      110009889882

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fieldwork program in the Republic of Zambia - health seminar by nursing students2015

    • Author(s)
      Inoue S, Zingani E, Ibuki A, Akase T
    • Journal Title

      Yokohama Journal of Nursing

      Volume: 8(1) Pages: 49-56

    • NAID

      110009889886

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Education for translational nursing between basic science and clinical practices2014

    • Author(s)
      Akase T,Inoue S,Koyama H,Makihara H
    • Journal Title

      Yokohama Journal of Nursing

      Volume: 7(1) Pages: 47-52

    • NAID

      110009839173

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aging-like skin changes in metabolic syndrome model mice are mediated by mineralocorticoid receptor signaling2013

    • Author(s)
      Nagase T, Asada M (13名中7番)
    • Journal Title

      Aging Cell

      Volume: 12 Issue: 1 Pages: 50-57

    • DOI

      10.1111/acel.12017

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 肥満マウスの紫外線照射による炎症性皮膚障害に対するKaempferia Parvifloraの有効成分の検討2015

    • Author(s)
      日高萌子、堀川和政、伊吹愛、松本裕、槇原弘子、袴田仁人、赤瀬智子
    • Organizer
      第3回看護理工学会
    • Place of Presentation
      立命館大学朱雀キャンパス(京都府京都市)
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肥満者における皮膚バリア機能に関連する因子の評価2015

    • Author(s)
      堀江良子、堀川和政、伊吹愛、松本裕、赤瀬智子
    • Organizer
      第36回日本肥満学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] HOW OBESITY IMPAIRS HUMAN SKIN FUNCTIONS?2015

    • Author(s)
      Ai Ibuki, Yoshiko Horie, Kazumasa Horikawa, Yutaka Matxumoto, Tomoko Akase
    • Organizer
      The 5th International Academic Consortium for Sustainable Cities Symposium
    • Place of Presentation
      Yokohama City Port Opening Memorial Hall(Yokohama,Kanagawa)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 肥満による表皮の組織学的変化2015

    • Author(s)
      堀江良子、伊吹愛、赤瀬智子
    • Organizer
      弟24回日本創傷・オストミー失禁管理学会
    • Place of Presentation
      幕張メッセ 国際展示場(千葉県千葉市)
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 看護学におけるトランスレーショナルリサーチ研究 -肥満の皮膚障害に対するスキンケア方法の確立を目指して-2014

    • Author(s)
      赤瀬智子
    • Organizer
      基礎科学をもとにしたCo-Medical研究会
    • Place of Presentation
      山形大学(山形)
    • Year and Date
      2014-11-08
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 肥満による炎症性皮膚障害に対する生姜成分の抗炎症・抗酸化効果2014

    • Author(s)
      赤瀬智子, 伊吹愛, 槇原弘子, 松本裕, 井上聡
    • Organizer
      第21回日本未病システム学会
    • Place of Presentation
      千里ライフサイエンスサンタ―(大阪)
    • Year and Date
      2014-11-02
    • Related Report
      2014 Research-status Report
  • [Presentation] 肥満によるヒト皮膚組織の変化2014

    • Author(s)
      赤瀬智子, 伊吹愛, 堀江良子, 松本裕, 槇原弘子, 井上聡
    • Organizer
      日本肥満学会
    • Place of Presentation
      シーガイヤコンベンションセンター(宮崎)
    • Year and Date
      2014-10-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 肥満マウスの炎症性皮膚障害に対する生姜成分の抗炎症・抗酸化効果の検討2014

    • Author(s)
      赤瀬智子, 伊吹愛, 松本裕, 井上聡
    • Organizer
      第2回看護理工学会
    • Place of Presentation
      大阪大学豊中キャンパス(大阪)
    • Year and Date
      2014-10-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 肥満女性の皮膚組織における軽度炎症とヒスタミンの評価2014

    • Author(s)
      伊吹愛, 赤瀬智子, 井上聡, 堀江良子
    • Organizer
      第2回看護理工学会
    • Place of Presentation
      大阪大学豊中キャンパス(大阪)
    • Year and Date
      2014-10-10
    • Related Report
      2014 Research-status Report
  • [Presentation] Aging-like skin changes occurred through mineralocorticoid receptor signling pathway in a mouse model for metabolic syndrome.

    • Author(s)
      Akase T, Ibuki A, Sanada H, Makihara H, Inoue S
    • Organizer
      Asia-Pacific Diabetes and Obesity Study Group Symposium
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] Metabolic syndrome モデルマウスの加齢性皮膚変化に対するミネラルコルチコイド受容体の関与

    • Author(s)
      赤瀬智子,伊吹愛,真田弘美
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] 食餌減量による肥満皮膚障害に対する予防効果の検討

    • Author(s)
      槇原弘子, 古田明子, 大橋健一, 井上聡, 堀江良子, 大門伶子, 鈴木亘, 鈴木祥太, 下島千明, 赤瀬智子
    • Organizer
      第20回日本未病システム学会学術総会
    • Place of Presentation
      学術情報センター(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] 肥満における皮膚障害に対するKP(Kaempferia parviflora)の予防効果の検討

    • Author(s)
      赤瀬智子, 竹内星爾, 槇原弘子, 井上聡
    • Organizer
      第20回日本未病システム学会学術総会
    • Place of Presentation
      学術情報センター(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] 肥満皮膚障害の病態メカニズム解析―肥満モデルマウスを使用した皮膚の組織学的検討

    • Author(s)
      槇原弘子, 日高萌子, 坂井佑衣, 堀江 良子, 井上 聡, 大橋 健一, 赤瀬 智子
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本市総合体育館(熊本)
    • Related Report
      2013 Research-status Report
  • [Presentation] Latent inflammation and oxidative stress in the skin of metabolic syndrome mice.

    • Author(s)
      Akase T,Nagase T,Ibuki A,Huang L,Horii M,Sugama J,Sanada H
    • Organizer
      4th Congress of the World Union of Wound Healing Societies
    • Place of Presentation
      パシィフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Oxidative stress mediates skin fragility in metabolic syndrome mice

    • Author(s)
      Ibuki A,Akase T,Nagase T, Minematsu T,Nakagami G, Horii M,Sugama J,Sanada H
    • Organizer
      4th Congress of the World Union of Wound Healing Societies
    • Place of Presentation
      パシィフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Ultrasonography reveals structural changes associated with increased oxidative stress in dermis of obese patients.

    • Author(s)
      Horii M,Sugama J,Minematsu T,Oe M,Nagase T,Yabunaka K,Akase T,Ibuki A,Miyanaga A,Sanada H
    • Organizer
      4th Congress of the World Union of Wound Healing Societies
    • Place of Presentation
      パシィフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 経時的紫外線照射によるmetabolic syndrome(MS)モデルマウスの皮膚変化

    • Author(s)
      赤瀬智子,長瀬敬,伊吹愛,須釜淳子,真田弘美
    • Organizer
      日本肥満学会
    • Place of Presentation
      ホテルグランヴィア京都(京都府)
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi