• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Relationship between 8-hydroxydeoxyguanosine levels in placental/umbilical cord blood and maternal/neonatal obstetric factors

Research Project

Project/Area Number 24593348
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Lifelong developmental nursing
Research InstitutionSapporo Medical University

Principal Investigator

EBINA Satoko  札幌医科大学, 保健医療学部, 講師 (50583738)

Co-Investigator(Kenkyū-buntansha) KASHIWAKURA Ikuo  弘前大学, 大学院保健学研究科, 教授 (00177370)
Co-Investigator(Renkei-kenkyūsha) MONZEN Satoru  弘前大学, 大学院保健学研究科, 助教 (20514136)
NISHINO Kayoko  青森中央学院大学, 准教授 (70091626)
Research Collaborator OZAKI Takashi  
YAMAGUCHI Masaru  
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords臍帯血 / 胎児 / 8-OHdG / 酸化ストレス / 分娩 / 臍帯動脈pH / 8-OHdG
Outline of Final Research Achievements

In the present study, to clarify the involvement of 8-OHdG contained in placental/umbilical cord blood (CB) during the perinatal period, the relationships between the levels of CB 8-OHdG and maternal/neonatal characteristics in vaginal deliveries were determined. The 8-OHdG levels in CB ranged from 0.1 to 1.39 ng/mL (median, 0.37 ng/mL). The 8-OHdG level detected in the nonsmoking group was significantly lower than that in the smoking group. However, no significant correlation was observed between 8-OHdG levels and other maternal/neonatal factors, including umbilical artery acid/base and gas values. In addition, significant positive correlations were observed between 8-OHdG levels and both placental weight and placental weight per infant birth weight (r = 0.343, p = 0.007; r = 0.368, p = 0.004, respectively). However, no significant correlations were observed between the 8-OHdG levels and infant birth weight.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (3 results)

  • [Journal Article] Relationship between feeding modes and neonatal weight gain in the first month after birth2013

    • Author(s)
      S.Ebina et al
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 5 Issue: 1 Pages: 28-32

    • DOI

      10.3892/etm.2012.741

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optimum time from collection to cell separation of human placental/umbilical cord blood for yield of mononuclear and CD34+ cells2013

    • Author(s)
      S.Ebina et al
    • Journal Title

      Journal of Health Science Research

      Volume: 3 Pages: 71-77

    • NAID

      40020250509

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of maternal body mass index on gestational weight gain and birth weight: A comparison of parity2013

    • Author(s)
      T. Chiba et al
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 6 Issue: 2 Pages: 293-298

    • DOI

      10.3892/etm.2013.1167

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of umbilical cord blood acid-base status and gas values on the yield of mononuclear cells and CD34+ cells2012

    • Author(s)
      S.Ebina et al
    • Journal Title

      Journal of Obstetrics and Gynacology Research

      Volume: 38 Pages: 997-1003

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Can umbilical arterial pH be a predictor of the yield of mononuclear and CD34+ cells found in placental/umbilical cord blood at full-term vaginal delivery?2012

    • Author(s)
      S.Ebina et al
    • Journal Title

      Journal of Health Science Research

      Volume: 2 Pages: 1-8

    • NAID

      40020236373

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationships between 8-hydroxy-deoxyguanosine levels in plasental/umbilical cord blood and maternal/neonatal obstetric factors2012

    • Author(s)
      S.Ebina et al
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 4 Issue: 3 Pages: 387-390

    • DOI

      10.3892/etm.2012.617

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Association between the levels of a DNA damage biomarker, 8-hydroxy-deoxyguanosine (8-OHdG), in placental/umbilical cord blood and maternal/neonatal characteristics at full-term birth.2014

    • Author(s)
      S. Ebina, T. Kogawa and I. Kashiwakura
    • Organizer
      XXIV European Congress on Perinatal Medicine
    • Place of Presentation
      Florence (Italy)
    • Year and Date
      2014-06-04 – 2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Association between oxidative stress and family history of hypertension.2014

    • Author(s)
      T. Kogawa, S. Ebina, and I. Kashiwakura.
    • Organizer
      XXIV European Congress on Perinatal Medicine
    • Place of Presentation
      Florence (Italy)
    • Year and Date
      2014-06-04 – 2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト胎児/新生児造血幹/前駆細胞の放射線感受性における胎盤臍帯血内酸塩基状態/ガス値の関与2012

    • Author(s)
      山口平 他
    • Organizer
      日本放射線影響学会 第55回大会
    • Place of Presentation
      仙台市
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi