Relationship between 8-hydroxydeoxyguanosine levels in placental/umbilical cord blood and maternal/neonatal obstetric factors
| Project/Area Number |
24593348
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Lifelong developmental nursing
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
EBINA Satoko 札幌医科大学, 保健医療学部, 講師 (50583738)
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| Co-Investigator(Kenkyū-buntansha) |
KASHIWAKURA Ikuo 弘前大学, 大学院保健学研究科, 教授 (00177370)
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| Co-Investigator(Renkei-kenkyūsha) |
MONZEN Satoru 弘前大学, 大学院保健学研究科, 助教 (20514136)
NISHINO Kayoko 青森中央学院大学, 准教授 (70091626)
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| Research Collaborator |
OZAKI Takashi
YAMAGUCHI Masaru
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 臍帯血 / 胎児 / 8-OHdG / 酸化ストレス / 分娩 / 臍帯動脈pH / ８－OHｄG |
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| Outline of Final Research Achievements |
In the present study, to clarify the involvement of 8-OHdG contained in placental/umbilical cord blood (CB) during the perinatal period, the relationships between the levels of CB 8-OHdG and maternal/neonatal characteristics in vaginal deliveries were determined. The 8-OHdG levels in CB ranged from 0.1 to 1.39 ng/mL (median, 0.37 ng/mL). The 8-OHdG level detected in the nonsmoking group was significantly lower than that in the smoking group. However, no significant correlation was observed between 8-OHdG levels and other maternal/neonatal factors, including umbilical artery acid/base and gas values. In addition, significant positive correlations were observed between 8-OHdG levels and both placental weight and placental weight per infant birth weight (r = 0.343, p = 0.007; r = 0.368, p = 0.004, respectively). However, no significant correlations were observed between the 8-OHdG levels and infant birth weight.
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Report
(4 results)
Research Products
(9 results)
