Novel functions of surface and intracellular muscarinic receptors in central nervous system and stress
Project/Area Number |
24600006
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
子ども学(子ども環境学)
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Research Institution | Kanazawa Medical University (2014) University of Fukui (2012-2013) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
NISHIMUNE Atsushi 福井大学, 医学部, 助教 (40311310)
UWADA Jyunsuke 旭川医科大学, 医学部, 助教 (70580314)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
|
Keywords | ムスカリン受容体 / アセチルコリン / 記憶 / ストレス / 大脳皮質 / 発達 / 海馬 / アセチルコリントランスポーター |
Outline of Final Research Achievements |
M1-muscarinic acetylcholine receptors (mAChRs) exist not only on cell surface but also at intracellular sites in the cerebral cortex and hippocampus. ACh acts on surface and intracellular mAChRs and activates distinct signaling pathways, involving in cholinergic facilitation of long-term potentiation in hippocampus. Stress selectively inhibits the expression of intracellular M1-mAChRs in cerebral cortez and hippocampus, probably leading the redunction of higher brain functions. The present results suggest cholinergic dual transmission in central nervous system and may give a significant clue to explore higher brain functions.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Activation of focal adhesion kinase via M1 muscarinic acetylcholine receptor is required in restitution of intestinal barrier function after epithelial injury2014
Author(s)
Khan RIM, Yazawa T, Anisuzzaman ASM, Semba S, Ma Y, Uwada J, Hayashi H, Suzuki Y, Ikeuchi H, Uchino Y, Maemoto T, Muramatsu I, Taniguchi T.
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Journal Title
Biochimica et Biophysica Acta - Molecular Basis of Disease
Volume: 1842/4
Pages: 635-645
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Novel contribution of cell surface and intracellular M1-muscarinic acetylcholine receptors to synaptic plasticity in hippocampus2013
Author(s)
Anisuzzaman ASM, Uwada J, Masuoka T, Yoshiki H, Nishio M, Ikegaya Y, Takahashi N, Matsuki N, Fujibayashi Y, Yonekura Y, Momiyama T, Muramatsu I.
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Journal Title
Journal of Neurochemistry
Volume: 126
Pages: 360-371
Related Report
Peer Reviewed
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[Journal Article] M1 is a major subtype of muscarinic acetylcholine receptors on mouse colonic epithelial cells2013
Author(s)
Khan RIM, Anisuzzaman ASM, Semba S, Ma Y, Uwada J, Hayashi H, Suzuki Y, Takano T, Ikeuchi H, Uchino M, Maemoto A, Ushikubi F, Muramatsu I, Taniguchi T
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Journal Title
Journal of Gastroenterology
Volume: 45
Pages: 885-896
NAID
Related Report
Peer Reviewed
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[Journal Article] M1 ia a major subtype of muscarinic acetylcholine receptors on mouse colonic epitjelial cells2013
Author(s)
Khan MR, Anisuzzaman AS, Semba S, Ma Y, Uwada J, Hayashi H, Suzuki Y, Takano T, Ikeuti H, Uchino M, Ushikubi F, Muramatsu I, Taniguchi T
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Journal Title
J Gastroenterol
Volume: in press
Issue: 8
Pages: 885-896
DOI
Related Report
Peer Reviewed