Development of treatment methods based on the neural substrates of fatigue - Relationship between chronic fatigue and internet addiction -

• Project/Area Number: 24600014
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 子ども学(子ども環境学)
• Research Institution: Kumamoto University
• Principal Investigator: KAWATANI Junko 熊本大学, 医学部附属病院, 非常勤診療医師 (30423669)
• Co-Investigator(Kenkyū-buntansha): MIZUNO Kei 独立行政法人理化学研究所, 研究員 (60464616) ; 上土井 貴子 熊本大学, 医学部附属病院, 助教 (90363522)
• Co-Investigator(Renkei-kenkyūsha): JOUDOI Takako 熊本大学, 医学部附属病院, 助教 (90363522)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 疲労 / 意欲 / 報酬 / 自律神経 / 思春期 / 線条体 / ドーパミン / 依存 / 小児慢性疲労症候群 / インターネット依存症 / 機能的磁気共鳴画像法（fMRI） / 自律神経機能 / 小児型慢性疲労症候群 / ・インターネット依存症 / 機能的磁気共鳴画像法

Outline of Final Research Achievements

The aim of this study was to clarify the neural substrates associated with motivation and reward systems and develop the methods for decrease and prevention of fatigue by controlling the autonomic nerve activity based on an objective evaluation of postexertional fatigue using the autonomic nerve function in patients with childhood chronic fatigue syndrome (CCFS) and internet addiction disorders. Decreases in the striatal activity and ability to regulate the autonomic nerve activity were observed in CCFS patients. We could develop the neurophysiological investigation methods for a treatment of dopaminergic system, regulation of autonomic nerve function and the objective evaluation for these interventions in CCFS patients.

Research Products

• [Journal Article] 小児・思春期の疲労・慢性疲労による意欲低下 (2014)
  • Author(s): 水野敬，友田明美，渡辺恭良
  • Journal Title: 日本疲労学会誌 Volume: 14 Pages: 101-103
  • Acknowledgement Compliant
• [Journal Article] Neurocognitive impairment in childhood chronic fatigue syndrome (2013)
  • Author(s): Mizuno Kei
  • Journal Title: Frontiers in Physiology Volume: 4 Pages: 87-87
  • DOI: 10.3389/fphys.2013.00087
  • Peer Reviewed
• [Presentation] Attentional and motivational deficits in patients with childhood chronic fatigue syndrome. (2014)
  • Author(s): Mizuno K, , Tajima K, Sasaki AT, Kawatani J, Joudoi T, Yoneda T, Tomoda A & Watanabe Y
  • Organizer: 11th IACFS/ME Biennial International Research and Clinical Conference
  • Place of Presentation: Parc 55 Wyndham Union Square Hotel (San Fransico), USA
• [Presentation] Low striatal activity during reward perception caused by adolescent chronic fatigue
  • Author(s): Mizuno K, Tajima K, Kawatani J, Joudoi T, Yoneda T, Tomoda A, & Watanabe Y
  • Organizer: The 36th Annual Meeting of the Japan Neuroscience Society (Neuro 2013)
  • Place of Presentation: Kyoto International Conference Center (Kyoto)
• [Presentation] 小児の疲労・慢性疲労による意欲低下の神経基盤
  • Author(s): 水野 敬
  • Organizer: 第9回日本疲労学会総会・学術集会
  • Place of Presentation: 秋田県総合保健センター（秋田