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Accumulation of repeated irradiation on children's health

Research Project

Project/Area Number 24600029
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field 子ども学(子ども環境学)
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

SHIMADA Yoshiya  独立行政法人放射線医学総合研究所, 放射線防護研究センター, 副センター長 (10201550)

Co-Investigator(Kenkyū-buntansha) NISHIMURA Mayumi  国立研究開発法人放射線医学総合研究所, 放射線防護研究センター, 主任研究員 (70218204)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords放射線 / 発がん / 子ども / 健康影響 / 小児 / 放射線診療 / 反復被ばく / 知識の普及
Outline of Final Research Achievements

Children are known to be susceptible to radiation-associated health effects. Recent public concern is focued on the repeated CT examination, especially to children. In this study, the effect of repeated exposure was compared to acute exposure in both infant (1 week of age) and adult (7 week of age) mice. It turned out that the effect of radiation on lifespan shortening and T-cell lymphoma development in infant mice was dependent on the interval of each exposure: the daily exposure was more effective than weekly exposure and acute exposure. On the other hand, the effect on adult mice showed no dependence on exposure regimen.
The local survey for childhood CT exposure was conducted. As a result, CTDI and DLP were almost comparble to international DRL. The numerical values of various CT examinations after nationa-wide survey were adopted as Japan national DRL.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (20 results)

All 2015 2014 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (11 results) (of which Invited: 9 results) Book (4 results)

  • [Journal Article] OPTIMISED PAEDIATRIC CT DOSE ATATERTIARY CHILDREN’S HOSPITAL IN JAPAN: A 4-Y SINGLE-CENTRE ANALYSIS2015

    • Author(s)
      Nakada Y., Shimada, Y et al.
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 未定 Issue: 1 Pages: 61-71

    • DOI

      10.1093/rpd/ncv004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methodological extensions of meta-analysis with excess relative risk estimates: application to risk of second malignant neoplasms among childhood cancer survivors treated with radiotherapy2014

    • Author(s)
      Doi T., Mieno M, Shimada Y., et al.
    • Journal Title

      Journal of Radiation Research

      Volume: 55 Issue: 5 Pages: 885-901

    • DOI

      10.1093/jrr/rru045

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fetal irradiation induces persistent translocations in rat mammary epithelial cells.2014

    • Author(s)
      Nakano, M,, Nishimura, M., Hamasaki, K., Mishima, S., Yoshida. M., Nakata. A., Shimada, Y., Noda, A.
    • Journal Title

      Radiation Res.

      Volume: 181(2) Issue: 2 Pages: 172-176

    • DOI

      10.1667/rr13446.1

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Age dependence of hematopoietic progenitor survival and chemokine family gene induction after gamma-irradiation in bone marrow tissue in C3H/He mice.2013

    • Author(s)
      Kentaro Ariyoshi, Takashi Takabatake, Mayumi Shinagawa, Kyoko Kadono, Kazuhiro Daino, Tatsuhiko Imaoka, Shizuko Kakinuma, Mayumi Nishimura, Yoshiya Shimada
    • Journal Title

      Radiation Research

      Volume: 181 Issue: 3 Pages: 302-313

    • DOI

      10.1667/rr13466

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of age on the relative biological effectiveness of carbon ion radiation for induction of rat mammary carcinoma.2013

    • Author(s)
      Imaoka T, Nishimura M, Daino K, Kokubo T, Doi K, Iizuka D, Nishimura Y, Okutani T, Takabatake M, Kakinuma S, Shimada Y
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 85 Issue: 4 Pages: 1134-40

    • DOI

      10.1016/j.ijrobp.2012.08.035

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Critical age windows of radiation exposure for cancer risk in experimental animal models2014

    • Author(s)
      Shimada Y., Nishimura M., et al.
    • Organizer
      EACR23
    • Place of Presentation
      ミュンヘン
    • Year and Date
      2014-08-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Age related differences in susceptibility to radiation-induced mammary carcinogenesis in rats2014

    • Author(s)
      Shimada Y.
    • Organizer
      AACR Annual meeting 2014
    • Place of Presentation
      サンディエゴ
    • Year and Date
      2014-04-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Critical age windows of radiation exposure for cancer risk in experimental animal models2014

    • Author(s)
      Shimada Y., Nishimura M., Imaoka T., Daino K., Yamada Y., Ariyoshi K., Tsuruoka C., Tani S.,Shang Y., Sakairi S., Hosoki A., Blyth B., Takeda S., Ishida Y., Kokubo T., Kakinuma S.
    • Organizer
      6th International systems radiation biology workshop
    • Place of Presentation
      千葉
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 発達期の被ばくによる発がんリスク2014

    • Author(s)
      島田義也、西村まゆみ、今岡達彦、臺野和広、山田裕、柿沼志津子
    • Organizer
      第16回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Critical age windows of radiation exposure for neoplasm induction in experimental animals2013

    • Author(s)
      Shimada Y., Nishimura M., Shang Y., Tsuruoka C., Amasaki Y., Ariyoshi K., Inoue T., Ishida Y., Imaoka T., Yamada Y., Kakinuma S.
    • Organizer
      29th RBC-NIRS International Symposium
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Age dependence of radiation carcinogenesis in animal models2013

    • Author(s)
      Shimada Y., Nishimura M., Ariyoshi K., Tani S., Ishida Y., Tsuruoka C., Imaoka T., Yamada Y., Takeda S., Amasaki Y., Shang Y., Sawai T., Sakairi S., Iwata K., Hosoki A., Morioka M., Kakinuma S.
    • Organizer
      International workshop on the biological effects of low dose radiation
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 妊娠と放射線2013

    • Author(s)
      島田 義也 , 仲田 佳広 , 小原 哲 , 青天目 州晶 , 盧 暁光
    • Organizer
      第69回日本放射線技術学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 胎児・こどもの放射線影響と医療被ばく2013

    • Author(s)
      島田義也
    • Organizer
      「医療放射線の安全利用」フォーラム
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 小児専門病院CT撮影線量実態調査2012

    • Author(s)
      仲田佳広、島田義也、他
    • Organizer
      第40回 日本放射線技術学会秋期学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Effect of radiation on children2012

    • Author(s)
      Y. Shimada
    • Organizer
      The 3rd workshop of science and values in radiological protection decision making. OECD/NEA
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] AGE DEPENDENCE OF RADIATION CARCINOGENESIS IN MOUSE AND RAT MODELS2012

    • Author(s)
      Y. Shimada、M. Nishimura、K. Daino、T. Imaoka、Y. Yamada、S. Takeda、Y.Shang、Y. Amasaki、T. Sawai、K. Iwata、T. Kokubo、Y. Ishida、S. Kakinuma
    • Organizer
      The 25th International Symposium Foundation for Promotion of Cancer Research "Radiation and Cancer"
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 低線量被ばくKEY BOOK : 正しい知識で深く理解する!2012

    • Author(s)
      島田義也、西村まゆみ、柿沼志津子、今岡達彦、他(分担)
    • Total Pages
      168
    • Publisher
      Medical Eye
    • Related Report
      2012 Research-status Report
  • [Book] 地震・津波・原発事故・放射線 (サイエンスカフェにようこそ! : 科学と社会が出会う場所)2012

    • Author(s)
      島田義也(分担)
    • Total Pages
      298
    • Publisher
      冨山房インターナショナル
    • Related Report
      2012 Research-status Report
  • [Book] 改訂版 虎の巻 低線量放射線と健康影響2012

    • Author(s)
      土居雅広、神田玲子、島田義也、他(分担)
    • Total Pages
      204
    • Publisher
      医療科学社
    • Related Report
      2012 Research-status Report
  • [Book] 放射線医療技術叢書(31)図解放射線防護ミニマム基礎知識2012

    • Author(s)
      島田義也、磯部智範、他(分担)
    • Total Pages
      109
    • Publisher
      日本放射線技術学会
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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