Accumulation of repeated irradiation on children's health
Project/Area Number |
24600029
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
子ども学(子ども環境学)
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Research Institution | National Institute of Radiological Sciences |
Principal Investigator |
SHIMADA Yoshiya 独立行政法人放射線医学総合研究所, 放射線防護研究センター, 副センター長 (10201550)
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Co-Investigator(Kenkyū-buntansha) |
NISHIMURA Mayumi 国立研究開発法人放射線医学総合研究所, 放射線防護研究センター, 主任研究員 (70218204)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 放射線 / 発がん / 子ども / 健康影響 / 小児 / 放射線診療 / 反復被ばく / 知識の普及 |
Outline of Final Research Achievements |
Children are known to be susceptible to radiation-associated health effects. Recent public concern is focued on the repeated CT examination, especially to children. In this study, the effect of repeated exposure was compared to acute exposure in both infant (1 week of age) and adult (7 week of age) mice. It turned out that the effect of radiation on lifespan shortening and T-cell lymphoma development in infant mice was dependent on the interval of each exposure: the daily exposure was more effective than weekly exposure and acute exposure. On the other hand, the effect on adult mice showed no dependence on exposure regimen. The local survey for childhood CT exposure was conducted. As a result, CTDI and DLP were almost comparble to international DRL. The numerical values of various CT examinations after nationa-wide survey were adopted as Japan national DRL.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Fetal irradiation induces persistent translocations in rat mammary epithelial cells.2014
Author(s)
Nakano, M,, Nishimura, M., Hamasaki, K., Mishima, S., Yoshida. M., Nakata. A., Shimada, Y., Noda, A.
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Journal Title
Radiation Res.
Volume: 181(2)
Issue: 2
Pages: 172-176
DOI
Related Report
Peer Reviewed
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[Journal Article] Influence of age on the relative biological effectiveness of carbon ion radiation for induction of rat mammary carcinoma.2013
Author(s)
Imaoka T, Nishimura M, Daino K, Kokubo T, Doi K, Iizuka D, Nishimura Y, Okutani T, Takabatake M, Kakinuma S, Shimada Y
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 85
Issue: 4
Pages: 1134-40
DOI
Related Report
Peer Reviewed
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[Presentation] Critical age windows of radiation exposure for cancer risk in experimental animal models2014
Author(s)
Shimada Y., Nishimura M., Imaoka T., Daino K., Yamada Y., Ariyoshi K., Tsuruoka C., Tani S.,Shang Y., Sakairi S., Hosoki A., Blyth B., Takeda S., Ishida Y., Kokubo T., Kakinuma S.
Organizer
6th International systems radiation biology workshop
Place of Presentation
千葉
Related Report
Invited
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[Presentation] Critical age windows of radiation exposure for neoplasm induction in experimental animals2013
Author(s)
Shimada Y., Nishimura M., Shang Y., Tsuruoka C., Amasaki Y., Ariyoshi K., Inoue T., Ishida Y., Imaoka T., Yamada Y., Kakinuma S.
Organizer
29th RBC-NIRS International Symposium
Place of Presentation
Kyoto
Related Report
Invited
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[Presentation] Age dependence of radiation carcinogenesis in animal models2013
Author(s)
Shimada Y., Nishimura M., Ariyoshi K., Tani S., Ishida Y., Tsuruoka C., Imaoka T., Yamada Y., Takeda S., Amasaki Y., Shang Y., Sawai T., Sakairi S., Iwata K., Hosoki A., Morioka M., Kakinuma S.
Organizer
International workshop on the biological effects of low dose radiation
Place of Presentation
Tokyo
Related Report
Invited
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[Presentation] 妊娠と放射線2013
Author(s)
島田 義也 , 仲田 佳広 , 小原 哲 , 青天目 州晶 , 盧 暁光
Organizer
第69回日本放射線技術学会
Place of Presentation
横浜
Related Report
Invited
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