Quantitative measurement of a new small animal SPECT/CT scanner with a semiconductor detector
Project/Area Number |
24601008
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
医学物理学・放射線技術学
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Research Institution | Kanazawa University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KAWAI Keiichi 金沢大学, 保健学系, 教授 (30204663)
HANAOKA Hirofumi 千葉大学, 薬学研究科, 助教 (50361390)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | SPECT / 半導体検出器 / 分子イメージング / 小動物用イメージング装置 / 定量測定 / 核医学 / PET / 小動物イメージング / 脳機能 / 腎機能 / 画像解析 |
Outline of Final Research Achievements |
In this study, we developed a quantitative measurement on a new small animal SPECT/CT scanners with a semiconductor detecotor.After assessment of performance on the scanners,seinsitivity of pinhole collimators was lower than that of parallel and slit collimators, while resolution was higher. Especially, eXplore speCZT CT120 was superior to another scanner on energy resolution. In addition, attenuation and resolution correction have kept quaitification of radioactive counts.However, we needed to develop new pinhole collimators for mice to yield higher resolution and for rats to yield higher sensitivity. The collimators provided 1.7 times resoulution for mice imaging and 2-3 times sensitivity for rats imaging.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Transport mechanisms of hepatic uptake and bile excretion in clinical hepatobiliary scintigraphy with 99mTc-N-pyridoxyl-5-methyltryptophan.2014
Author(s)
Kobayashi M, Nakanishi T, Nishi K, Higaki Y, Okudaira H, Ono M, Tsujiuchi T, Mizutani A, Nishii R, Tamai I, Arano Y, Kawai K.
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Journal Title
Nucl Med Biol
Volume: 4
Issue: 4
Pages: 338-342
DOI
Related Report
Peer Reviewed
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[Journal Article] Application of a medium-energy collimator for I-131 imaging after ablation treatment of differentiated thyroid cancer.2014
Author(s)
Kobayashi M, Wakabayashi H, Kayano D, Konishi T, Kojima H, Okuda K, Yoneyama H, Tsushima H, Onoguchi M, Kawai K, Kinuya S.
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Journal Title
Annuls of Nuclear medicine
Volume: 28
Issue: 6
Pages: 551-558
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Pharmacokinetic Alteration of 99mTc-MAG3 using Serum Protein Binding Displacement Method.2013
Author(s)
K Nishi, M Kobayashi, R Nishii, N Shikano, N Takamura, N Kuga, K Yamasaki, S Nagamachi, S Tamura, M Otagiri, K Kawai.
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Journal Title
Nucl Med Biol
Volume: 40
Issue: 3
Pages: 366-370
DOI
Related Report
Peer Reviewed
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[Journal Article] Diagnostic usefulness of an amino acid tracer, α-[N-methyl- ^11C]-methylaminoisobutyric acid ( ^<11>C-MeAIB), in the PET diagnosis of chest malignancies2013
Author(s)
Nishii R, Higashi T, Kagawa S, Kishibe Y, Takahashi M, Yamauchi H, Motoyama H, Kawakami K, Nakaoku T, Nohara J, Okamura M, Watanabe T, Nakatani K, Nagamachi S, Tamura S, Kawai K, Kobayashi M
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Journal Title
Ann Nucl Med
Volume: 27(9)
Issue: 9
Pages: 808-21
DOI
Related Report
Peer Reviewed
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[Journal Article] Prototype imaging protocols for monitoring the efficacy of iodine-131 ablation in differentiated thyroid cancer.2013
Author(s)
Kobayashi M, Wakabayashi H, Kojima H, Konishi T, Okuda K, Yoneyama H, Kayano D, Tobisaka H, Tsushima H, Onoguchi M, Kawai K, Kinuya S.
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Journal Title
Hellenic of Nuclear Medicine
Volume: 16
Pages: 175-180
Related Report
Peer Reviewed
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