Integrative intracranial-condition analysis using MRI

• Project/Area Number: 24601009
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 医学物理学・放射線技術学
• Research Institution: Kanazawa University
• Principal Investigator: MIYATI Tosiaki 金沢大学, 保健学系, 教授 (80324086)
• Co-Investigator(Kenkyū-buntansha): MASE Mitsuhito 名古屋市立大学, 医学研究科, 准教授 (60238920)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 医療・福祉 / 脳・神経 / 脳神経疾患 / 磁気共鳴画像(MRI) / バイオメカニクス / 特発性正常圧水頭症 / 水分子揺動 / 脳血流 / ハイドロダイナミックス

Outline of Final Research Achievements

To integratively analyze and evaluate the intracranial-condition, we developed a method for simultaneously obtaining functional information on diffusion and fluctuation of water molecules, biomechanical properties, and blood flow in brain using magnetic resonance imaging. We verified the validity of this method using an original phantom. The integrative intracranial-condition analysis-method made it possible to noninvasively assess more detailed and precise information on the intracranial state, and to assist in the clarification of idiopathic normal-pressure hydrocephalus.

Research Products

• [Journal Article] State of water molecular displacement of the brain during the cardiac cycle in idiopathic normal pressure hydrocephalus (2015)
  • Author(s): Kan H
  • Journal Title: Comput Med Imaging Graph Volume: 40 Pages: 88-93
  • DOI: 10.1016/j.compmedimag.2014.12.004
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Transfer characteristics of arterial pulsatile force in regional intracranial tissue using dynamic diffusion MRI: a phantom study (2014)
  • Author(s): Kan H
  • Journal Title: Magn Reson Imaging Volume: 32 Issue: 10 Pages: 1284-1289
  • DOI: 10.1016/j.mri.2014.08.026
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Delta-ADC (apparent diffusion coefficient) analysis in patients with idiopathic normal pressure hydrocephalus (2012)
  • Author(s): Osawa T
  • Journal Title: Acta Neurochir Suppl Volume: 114 Pages: 97-200
  • DOI: 10.1007/978-3-7091-0923-6_6
  • ISBN: 9783709109229, 9783709109236
• [Presentation] Novel triexponential analysis of intravoxel incoherent motion for brain perfusion and diffusion (2014)
  • Author(s): Ohno N
  • Organizer: 100th RSNA Meeting
  • Place of Presentation: McCormick Place (米国)
  • Year and Date: 2014-11-29 – 2014-12-04
• [Presentation] Hemodynamic-independent analysis with self correction for brain-fluctuation MRI (2014)
  • Author(s): Takatsuji M
  • Organizer: 100th RSNA Meeting
  • Place of Presentation: McCormick Place (米国)
  • Year and Date: 2014-11-29 – 2014-12-04
• [Presentation] Relationship between temporal changes of the regional apparent diffusion coefficient and intracranial compliance in idiopathic normal pressure hydrocephalus (2014)
  • Author(s): Mase M
  • Organizer: Hydrocephalus 2014
  • Place of Presentation: Bristol University (英国)
  • Year and Date: 2014-09-04 – 2014-09-08
• [Presentation] Water turnover in brain parenchyma and ventricles esrimated by dynamic PET using H215O (2014)
  • Author(s): Mase M
  • Organizer: Hydrocephalus 2014
  • Place of Presentation: Bristol University (英国)
  • Year and Date: 2014-09-04 – 2014-09-08
• [Presentation] Self correction of blood flow effect for brain-fluctuation MRI (2014)
  • Author(s): Takatsuji M
  • Organizer: ISMRM 22nd Scientific Meeting and Exhibition
  • Place of Presentation: MiCo Convention Center (イタリア)
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Time-SLIP with pencil beam pulse for observing CSF flow dynamics (2014)
  • Author(s): Shibukawa S
  • Organizer: ISMRM 22nd Scientific Meeting and Exhibition
  • Place of Presentation: MiCo Convention Center (イタリア)
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Integrated phantom analysis of perfusion, diffusion, and fluctuation MRI (2014)
  • Author(s): Ohno N
  • Organizer: ISMRM 22nd Scientific Meeting and Exhibition
  • Place of Presentation: MiCo Convention Center (イタリア)
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Water molecular fluctuation in ventricules and brain tissue in normal pressure hydrocephalus (2013)
  • Author(s): Mase M
  • Organizer: Hydrocephalus 2013 Athens
  • Place of Presentation: Athenaeum InterContinental Athens Hotel（ギリシャ）
• [Presentation] Cerebrospinal fluid fluctuation in the ventricular system in idiopathic normal pressure hydrocephalus (2013)
  • Author(s): Ohno N
  • Organizer: 99th RSNA Meeting
  • Place of Presentation: McCormick Place（米国）
• [Presentation] Development of cranial MRI-phantom for assessing perfusion, diffusion, and fluctuation (2013)
  • Author(s): Hiratsuka S
  • Organizer: 99th RSNA Meeting
  • Place of Presentation: McCormick Place（米国）
• [Presentation] Water fluctuation analysis in idiopathic normal pressure hydrocephalus: change in tap test (2013)
  • Author(s): Asano A
  • Organizer: ECR 2013
  • Place of Presentation: Vienna International Centre（オーストリア）
• [Presentation] Triexponential analysis on diffusion MRI in brain (2013)
  • Author(s): Asano A
  • Organizer: ECR 2013
  • Place of Presentation: Vienna International Centre（オーストリア）
• [Presentation] Analysis of ADC change during cardiac cycle in idiopathic normal pressure hydrocephalus: change in tap test (2012)
  • Author(s): Asano A
  • Organizer: ISMRM 20th Scientific Meeting and Exhibition
  • Place of Presentation: Melbourne Convention & Exhibition Centre（オーストラリア）
• [Presentation] Water amount independent analysis of fluctuated water molecules in idiopathic normal pressure hydrocephalus (2012)
  • Author(s): Ohno N
  • Organizer: ISMRM 20th Scientific Meeting and Exhibition
  • Place of Presentation: Melbourne Convention & Exhibition Centre（オーストラリア）
• [Presentation] Changes of the regional apparent diffusion coefficient of the brain during the cardiac cycle in patients with idiopathic normal pressure hydrocephalus (2012)
  • Author(s): Mase M
  • Organizer: Hydrocephalus 2012 Kyoto
  • Place of Presentation: ウェスティン都ホテル京都（京都府）
• [Presentation] Fast phase-contrast cine-MRI for assessing intracranial condition (2012)
  • Author(s): Noda T
  • Organizer: 98th RSNA Meeting
  • Place of Presentation: McCormick Place（米国）
• [Presentation] Normalized ΔADC in idiopathic normal pressure hydrocephalus (2012)
  • Author(s): Ohno N
  • Organizer: 98th RSNA Meeting
  • Place of Presentation: McCormick Place（米国）
• [Book] 標準 MRIの評価と解析 (2012)
  • Author(s): 宮地 利明
  • Total Pages: 240
  • Publisher: オーム社
• [Remarks] Miyati Laboratory
  • URL: http://miyatilab.w3.kanazawa-u.ac.jp/publications/index.htm
• [Remarks] Miyati Laboratory
  • URL: http://miyatilab.w3.kanazawa-u.ac.jp
• [Remarks] Miyati Laboratory
  • URL: http://miyatilab.w3.kanazawa-u.ac.jp