Development of a full three dimensional dose distribution measurement system for intensity modulated proton therapy

• Project/Area Number: 24601013
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 医学物理学・放射線技術学
• Research Institution: Nagoya City University
• Principal Investigator: TOSHITO Toshiyuki 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (30377965)
• Co-Investigator(Renkei-kenkyūsha): NAKAMURA Mitsuhiro 名古屋大学, 大学院理学研究科, 教授 (90183889)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 強度変調陽子線治療 / シンチレーティングファイバー / 品質管理 / 陽子線治療 / シンチレーションファイバー

Outline of Final Research Achievements

We developed fully three-dimensional dose distribution measurement system for the purpose of quality assurance for intensity modulated proton therapy. A scintillating fiber block was used as a detector. We manufactured it by stacking approximately 18000 500 μm-diameter-scintillating fibers. It measures 90 mm x 62 mm x 107 mm. We conducted beam test to measure basic characteristics of the detector by using proton beam at Nagoya Proton Therapy Center. Measurements of dose distribution for double-scattered and spot scanning irradiation were carried out by taking images with the 10 degree step rotation of the detector system. A software to reconstruct three-dimensional dose distribution using a Maximum-Likelihood Expectation Maximization algorithm was developed. Finally we obtained 1 mm pitch dose distribution by using this system.

Research Products

• [Presentation] Calculation method of secondary neutron induced dose in proton scanning beam delivery system using aperture (2015)
  • Author(s): 歳藤利行、大町千尋、岐部佳朗、林建佑、柴田洋希、安井啓祐、磯山茂、荻野浩幸、岩田宏満、溝江純悦
  • Organizer: 第109回 医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2015-04-18
• [Presentation] Irradiation method for lung and liver cancer and QA using scanning beam: An attempt in Nagoya Proton Therapy Center (2015)
  • Author(s): 歳藤利行、大町千尋、岐部佳朗、林建佑、柴田洋希、安井啓祐、田中堅一郎、鈴木利徳、磯山茂、荻野浩幸、岩田宏満、溝江純悦
  • Organizer: 第109回 医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2015-04-16
• [Presentation] Geant4の概要と医学応用 (2015)
  • Author(s): 歳藤利行
  • Organizer: 日本原子力学会春の年会
  • Place of Presentation: 茨城大学（茨城県)
  • Year and Date: 2015-03-22
  • Invited
• [Presentation] Commissioning of proton beam spot scanning irradiation system with energy absorber and aperture in Nagoya Proton Therapy Center (2014)
  • Author(s): 歳藤利行、大町千尋、安井啓祐、林建佑、岐部佳朗、菅井裕之、柴田洋希、田中堅一郎、仁川英紀、浅井久美子、下村朗、木納英登、磯山茂、荻野浩幸、岩田宏満、溝江純悦
  • Organizer: The 7th KOREA-JAPAN Joint Meeting on Medical Physics
  • Place of Presentation: プサン（韓国)
  • Year and Date: 2014-09-27
• [Presentation] Clinical experience of Monte Carlo dose calculation in proton therapy using spot scanning irradiation system in Nagoya Proton Therapy Center (2014)
  • Author(s): 歳藤利行、大町千尋、安井啓祐、林建佑、岐部佳朗、菅井裕之、田中堅一郎、仁川英紀、浅井久美子、下村朗、木納英登、磯山茂、荻野浩幸、岩田宏満、溝江純悦
  • Organizer: The 7th KOREA-JAPAN Joint Meeting on Medical Physics
  • Place of Presentation: プサン(韓国)
  • Year and Date: 2014-09-26
• [Presentation] シンチレーションファイバーを用いた粒子線治療のための3次元線量分布測定システム (2013)
  • Author(s): 歳藤利行
  • Organizer: 第106回日本医学物理学会学術大会
  • Place of Presentation: 大阪大学コンベンションセンター(大阪)
• [Remarks] 名古屋陽子線治療センター 論文・研究発表実績
  • URL: http://www.nptc.city.nagoya.jp/action/research.html
• [Remarks] 論文・研究発表実績|名古屋陽子線治療センター
  • URL: http://www.nptc.city.nagoya.jp/action/research.html