Analysis of dynamical behavior of cell- ECM interaction related to tissue sclerosises diseases
| Project/Area Number |
24604001
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Mechanobiology
|
|---|
| Research Institution | 社会医療法人社団蛍水会名戸ヶ谷病院（ロコモティブシンドローム研究所メカノメディス (2014)
Tokyo Institute of Technology (2012-2013) |
|---|
Principal Investigator |
HARADA Ichiro 社会医療法人社団蛍水会名戸ヶ谷病院(ロコモティブシンドローム研究所メカノメディス, メカノメディスン部門, 主任研究員 (00361759)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 細胞外マトリクス / メカノトランスダクション / 弾性材料 / 物性評価 / 生体恒常性 / 組織硬化 / 組織物性 / 細胞接着 |
|---|
| Outline of Final Research Achievements |
Recently, a number of studies suggested stiffness of tissue affect many of the diseases such as malignant alteration of cancer and heart remodeling. Most of the cells adhere to the extracellular matirices effected by its elasticity and those sensing process has been focused as a new type of mechanotransduction. Because many of similarities can be concerned between this mechanotransduction and stimuli of mechanical stress via external forces, similar molecular mechanisms have been proposed as mechanosensing. However, those approaches are shown as transient and immediate molecular processes that how cellular functions or signaling profiles altered in longer-term on soft or stiff substrate is still open question. In this study, we focused on cellular signaling profile which varies in longer-term and propose mechanism a key function involves in sclerosis diseases.
|
Report
(4 results)
Research Products
(11 results)
-
-
-
[Journal Article] p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion.2014
Author(s)
Yamauchi S, Hou YY, Guo AK, Hirata H, Nakajima W, Yip AK, Yu CH, Harada I, Chiam KH, Sawada Y, Tanaka N, Kawauchi K.
-
Journal Title
J Cell Biol.
Volume: 204
Issue: 7
Pages: 1191-207
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
[Journal Article] Dual Inhibition of Src and GSK3 Maintains Mouse Embryonic Stem Cells, Whose Differentiation Is Mechanically Regulated by Src Signaling.2012
Author(s)
Shimizu, T., Ueda, J., Ho, J.C., Iwasaki, K., Poellinger, L., Harada, I., and Sawada, Y.
-
Journal Title
Stem Cells
Volume: 30
Issue: 7
Pages: 1394-1404
DOI
Related Report
Peer Reviewed
-
-
-
-
