Development of adsorbents which recognized molecular structure based on chemical affinity and its application to pesticide residue analysis

• Project/Area Number: 24612003
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Reliable environmental measurement methods
• Research Institution: Chubu University
• Principal Investigator: YAMAMOTO Atsushi 中部大学, 応用生物学部, 教授 (60360806)
• Co-Investigator(Kenkyū-buntansha): KODAMA Shuji 東海大学, 理学部, 教授 (70360807)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 選択的吸着剤 / 食品危害因子 / 簡易スクリーニング / 双極子モーメント / 食品分析 / 危害因子 / ハロゲン化合物 / オンレジン蛍光分析法 / 化学的親和力

Outline of Final Research Achievements

We made clear that not only strong intermolecular interactions but also weak interactions play an important role in the adsorbents. A solute is drawn to the adsorbent by long-range strong intermolecular interactions and comes closest to a functional group by short-range weak intermolecular interactions. Desorption of a solute which was firmly immobilized on the functional group by mixed intermolecular interactions once becomes difficult. The development of highly selective adsorbents requires no additional separation procedures. We constructed a new device named “on-resin fluorescence analysis”, and established the simple method to measure trace amounts of tetracycline antibiotics in honey samples by this device.

Research Products

• [Journal Article] Design and development of a suitable adsorbent to capture theophylline for non-invasive therapeutic drug monitoring with exhaled breath (2015)
  • Author(s): Atsushi Yamamoto, Sayaka Hioki, Chihiro Tanada, Toshio Miwa, Yoshinori Inoue, Ryohei Yamamoto, Miyoko Matsushima, Tsutomu Kawabe
  • Journal Title: Analytical Methods Volume: 7 Issue: 2 Pages: 423-427
  • DOI: 10.1039/c4ay02243b
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Retention behavior of halogenated benzenes on a stationary phase having 2,4-dibromophenoxy group as the halogen recognition functional group (2015)
  • Author(s): Toshio Miwa, Shiho Suzuki, Rina Takai, Ryohei Yamamoto, Yoshinori Inoue, Atsushi Yamamoto
  • Journal Title: Analytical Sciences Volume: 31
  • NAID: 130005092128
  • Peer Reviewed / Open Access
• [Journal Article] Separation properties of saccharides on a hydrophilic stationary phase having hydration layer formed zwitterionic copolymer (2014)
  • Author(s): Waka Kamichatani, Yoshinori Inoue, Atsushi Yamamoto
  • Journal Title: Analytica Chimica Acta Volume: 853 Pages: 602-607
  • DOI: 10.1016/j.aca.2014.09.025
  • Peer Reviewed
• [Journal Article] Retention of halogenated solutes on stationary phases containing heavy atoms (2013)
  • Author(s): Toshio Miwa, Atsushi Yamamoto, Mitsuru Saito, Yoshinori Inoue
  • Journal Title: Molecules Volume: 18 Issue: 5 Pages: 5167-5171
  • DOI: 10.3390/molecules18055163
  • Peer Reviewed
• [Journal Article] An optosensing device for detecting tetracycline antibiotics in honey (2013)
  • Author(s): Atsushi Yamamoto, Saori Yoshii, Chika Suematsu, Michiya Tatematsu, Hidenori Shoji, Yuji Kato, Mitsuru Saito, Yoshinori Inoue
  • Journal Title: Analytical Methods Volume: 5 Issue: 3 Pages: 773-777
  • DOI: 10.1039/c2ay25667c
  • Peer Reviewed
• [Presentation] 配位子交換作用を付加した両性イオン型高分子結合分離剤によるカビ毒の抽出 (2015)
  • Author(s): 日置清香、谷畑壮磨、上茶谷若、井上嘉則、山本 敦
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 静電相互作用から双極子相互作用へ―選択性発現に向けて (2014)
  • Author(s): 山本 敦
  • Organizer: 日本分析化学会第63年会
  • Place of Presentation: 東広島
  • Year and Date: 2014-09-17 – 2014-09-19
  • Invited
• [Presentation] 2,4-Dibromophenoxy基を有する新規ポリマー分離剤の開発と誘起ハロゲン化合物に対する分離選択性の評価 (2014)
  • Author(s): 三輪俊夫、山本 敦、井上嘉則、齊藤 満
  • Organizer: 第74回分析化学討論会
  • Place of Presentation: 郡山
  • Year and Date: 2014-05-24 – 2014-05-25
• [Presentation] 新規液体クロマトグラフィー用固定相の開発とQSARパラメータを用いた溶質選択性の評価 (2013)
  • Author(s): 三輪俊夫、鈴木志穂、山本 敦、斎藤 勲、井上嘉則、齊藤 満
  • Organizer: 第73回分析化学討論会
  • Place of Presentation: 北海道大学函館キャンパス
• [Presentation] 新規吸着剤と化学発光検出フローインジェクション法によるウレア系薬剤の高感度迅速分析 (2013)
  • Author(s): 高井里奈、三輪俊夫、山本 敦、斎藤 勲、東海林秀典、加藤祐史、井上嘉則、齊藤 満
  • Organizer: 日本分析化学会第62年会
  • Place of Presentation: 近畿大学東大阪キャンパス
• [Presentation] ネオニコチノイド系農薬分析のためのインライン前処理-FIAシステムの構築 (2013)
  • Author(s): 吉井沙織、三輪俊夫、山本 敦、東海林秀典、加藤祐史、井上嘉則
  • Organizer: 日本分析化学会第62年会
  • Place of Presentation: 近畿大学東大阪キャンパス
• [Presentation] ニトロ化芳香環を有する新規LC用分離剤の開発とその分離特性の評価 (2013)
  • Author(s): 三輪俊夫、高井里奈、山本 敦、井上嘉則、齊藤 満
  • Organizer: 日本分析化学会第62年会
  • Place of Presentation: 近畿大学東大阪キャンパス
• [Presentation] 双極子を利用する固相抽出剤 (2012)
  • Author(s): 三輪俊夫、鈴木志穂、斎藤 勲、山本 敦、井上嘉則、齊藤 満
  • Organizer: 第72回分析化学討論会
  • Place of Presentation: 鹿児島大学
• [Presentation] 双極子認識型固相抽出剤による簡易農薬分析（その1）―ニトリル系除草剤 (2012)
  • Author(s): 鈴木志保、三輪俊夫、山本 敦、斎藤 勲、上野英二、井上嘉則、齊藤 満
  • Organizer: 日本分析化学会第61年会
  • Place of Presentation: 金沢大学
• [Presentation] 双極子認識型固相抽出剤による簡易農薬分析（その2）―ネオニコチノイド系殺虫剤 (2012)
  • Author(s): 三輪俊夫、鈴木志穂、山本 敦、斎藤 勲、上野英二、井上嘉則、齊藤 満
  • Organizer: 日本分析化学会第61年会
  • Place of Presentation: 金沢大学
• [Presentation] 双極子認識型固相抽出剤による簡易農薬分析（その3）―ハロゲン化フェノキシ酢酸系除草剤 (2012)
  • Author(s): 鈴木志保、三輪俊夫、山本 敦、斎藤 勲、上野英二、井上嘉則、齊藤 満
  • Organizer: 日本分析化学会第61年会
  • Place of Presentation: 金沢大学