| Project/Area Number |
24613005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
epigenetics
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| Research Institution | Kyushu University |
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Principal Investigator |
UNOKI MOTOKO 九州大学, 生体防御医学研究所, 助教 (30525374)
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| Research Collaborator |
MAENOHARA Shoji 九州大学, 生体防御医学研究所
OHISHI Hiroaki 九州大学, 生体防御医学研究所
TANAKA Tomohiro 九州大学, 医学部生命科学科
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | DNAメチル化 / ゲノムインプリンティング / UHRF1 / 発生 / 生殖細胞 / 初期発生 / エピジェネティクス / ヒストン修飾 / インプリンティング / リプログラミング / ノックアウトマウス |
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| Outline of Final Research Achievements |
Genomic imprinting is the epigenetic phenomenon by which certain genes are expressed in a parent-of-origin-specific manner based on imprinted information such as DNA methylation and/or histone modifications established during gametogenesis. Abnormal genomic imprinting can cause human congenital disorders. In this research, we examined whether UHRF1, which is one of important epigenetic regulators, has a role in establishment and/or maintenance of genomic imprinting, and found that UHRF1 is not involved in establishment of genomic imprinting during oogenesis, but has a critical role in maintenance of it during pre-implantation development against global DNA demethylation.
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