Nutritional status and clinical outcomes in patients with heart failure: Clinical nutritional epidemiology

• Project/Area Number: 24614001
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrated Nutrition Science
• Research Institution: Kitasato University
• Principal Investigator: MAKAYA Miyuki 北里大学, 看護学部, 准教授 (60415552)
• Co-Investigator(Kenkyū-buntansha): TSUTSUI Hiroyuki 北海道大学, 医学研究科, 教授 (70264017) ; KINUGAWA Shintaro 北海道大学, 医学研究科, 講師 (60399871)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 慢性心不全 / 栄養 / 臨床疫学 / Quality of life / 生命予後 / 疫学 / 栄養疫学

Outline of Final Research Achievements

The present study demonstrated that malnutrition in approximately half of patients with chronic heart failure (HF), and malnourished patients had low fatty acid and amino acid levels. Malnourished patients also exhibited reduced exercise tolerance and quality of life (QOL), as well as concurrent depressive symptoms. Patients with depressive symptoms and patients with reduced QOL were found to have significantly lower intake of vegetables, pulses, seaweed, and fruit. We found that malnutrition and dietary habits was closely associated with poor clinical outcomes in patients with HF. Therefore, patient outcome-based nutritional intervention for HF patients is needed.

Research Products

• [Journal Article] 超高齢者の心不全管理 リアルワールドでの困難へ挑む 超高齢者心不全のケア (2014)
  • Author(s): 眞茅みゆき
  • Journal Title: 内科 Volume: 113 Pages: 505-509
• [Journal Article] Characteristics, management, and outcomes for patients during hospitalization due to worsening heart failure-A report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD). (2013)
  • Author(s): Hamaguchi S1, Kinugawa S, Tsuchihashi-Makaya M, Goto D, Yamada S, Yokoshiki H, Tsutsui H
  • Journal Title: Journal of Cardiology Volume: 62 Issue: 2 Pages: 95-101
  • DOI: 10.1016/j.jjcc.2013.03.009
  • Peer Reviewed
• [Journal Article] Nutrition as a new treatment target in chronic heart failure. (2013)
  • Author(s): Tsuchihashi-Makaya M, Kinugawa S
  • Journal Title: Circulation Journal Volume: 77 Pages: 604-605
  • NAID: 10031138945
• [Journal Article] 心疾患の栄養問題を考える (2012)
  • Author(s): 眞茅みゆき
  • Journal Title: HEART Volume: 2 Pages: 709-715
• [Presentation] Influence of nutritional status on depressive symptoms and quality of life in patients with heart failure (2014)
  • Author(s): Tsuchihashi-Makaya M, Fukushima A, Kinugawa S, Kinugasa Y, Ono T, Matsuo H, Okada A, Kato M, Yamamoto K, Tsutsui H
  • Organizer: American Heart Association Scientific Session 2014
  • Place of Presentation: 米国イリノイ州シカゴ
  • Year and Date: 2014-11-16
• [Presentation] 心不全とサルコペニア (2014)
  • Author(s): 絹川真太郎、福島新、眞茅みゆき、筒井裕之
  • Organizer: 第18回日本心不全学会学術集会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2014-10-12
• [Presentation] 心不全における骨格筋異常 (2014)
  • Author(s): 絹川真太郎、筒井裕之
  • Organizer: 第62回日本心臓病学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2014-09-27
• [Presentation] 血中脳由来性神経栄養因子（BDNF）の低下は慢性心不全患者の独立した予後規定因子である (2014)
  • Author(s): 福島新、絹川真太郎、横田卓、松島将士、正木芳弘、降旗高明、高田真吾、門口智泰、堀亨一、阿部隆宏、小島尚子、勝山亮一、沖田孝一、筒井裕之
  • Organizer: 第20回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 京都府京都市
  • Year and Date: 2014-07-19
• [Presentation] 慢性心不全の包括的疾病管理
  • Author(s): 眞茅みゆき
  • Organizer: 第15回石川県心臓リハビリテーション研究会
  • Place of Presentation: 石川県金沢市
  • Invited
• [Presentation] Poor nutritional status was independent determinant of muscle wasting in patients with heart failure
  • Author(s): 阿部隆宏、絹川真太郎、福島新、本間恒章、正木芳弘、降旗高明、眞茅みゆき、堀亨一、筒井裕之
  • Organizer: 第17回日本心不全学会学術集会
  • Place of Presentation: 埼玉県大宮市
• [Presentation] 慢性心不全患者に対する多職種による疾病管理プログラム
  • Author(s): 眞茅みゆき
  • Organizer: 第3回群馬臨床心不全研究会
  • Place of Presentation: 群馬県前橋市
  • Invited
• [Presentation] 慢性心不全患者における筋消耗に与える栄養指標の影響
  • Author(s): 阿部隆宏、絹川真太郎、福島新、本間恒章、正木芳弘、降旗高明、眞茅みゆき、堀亨一、筒井裕之
  • Organizer: 第19回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 宮城県仙台市
• [Book] 心不全診療Q&A：慢性心不全の疫学 (2015)
  • Author(s): 眞茅みゆき、筒井裕之
  • Total Pages: 459
  • Publisher: 中外医学社