Behavioral and neural mechanisms of sugar overconsumption
| Project/Area Number |
24614006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
ERINA Yamaguchi 大阪大学, 大学院人間科学研究科
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 過剰摂取行動 / 甘味刺激 / 動機づけ / 味覚嗜好性 / 味覚嗜好学習 / 扁桃体 / 行動訓練 / 嗜好性に基づく摂食 / 学習 / ストレス / ショ糖 / 過剰摂取 / 味覚感受性 / 高嗜好性飲食物 / 脳学習機構 / 脳内報酬系 |
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| Outline of Final Research Achievements |
The present project aimed to develop mouse models of hedonically motivated sugar overconsumption and sugar preference. In Study 1, limited access to a highly palatable sucrose solution and chow for 10 days caused binge-like sucrose overconsumption in food-deprived mice. The binge-like behavior was not disrupted by energetic restoration such as systemic administration of glucose and preload of chow, suggesting that the binge-like behavior is driven by hedonic motivation rather than metabolic need. Longer training accelerated its reinstatement after long abstinence. In Study 2, FD mice were alternately exposed sucrose and saccharin. Trained mice increased sucrose intake and preference for sucrose over an equally sweet-tasting non-caloric saccharin. Mice with selective lesions of the basolateral, but not central, amygdala did not show these behavioral preference for sucrose. Our study provides useful mouse models of hedonic motivated sugar overconsumption and preference for sugar reward.
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Report
(4 results)
Research Products
(28 results)
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[Presentation] Neural circuit contributing to control mechanism of body weight-dependent sucrose preference.2015
Author(s)
Asahina, Y., Eda-Fujiwara, H., Satoh, R., Yasoshima, Y., Tuneoka, Y., Miyamoto, T.
Organizer
第120回日本解剖学会総会･全国学術集会・第92回日本生理学会大会
Place of Presentation
神戸国際会議場・展示場（神戸市）
Year and Date
2015-03-21 – 2015-03-23
Related Report
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[Presentation] Control mechanism of sucrose preference by body weight.2014
Author(s)
Asahina, Y., Eda-Fujiwara, H., Satoh, R., Yasoshima, Y., Miyamoto, T.
Organizer
5th Ewha-JWU-Ochanomizu Joint Symposium 2014 （第5回 日韓３女子大学交流合同シンポジウム）
Place of Presentation
Seoul, Korea
Year and Date
2014-12-02 – 2014-12-04
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[Presentation] Contribution of amygdala to selective learned preference for a nutritive sweetener in mice.2014
Author(s)
Miyamoto, T., Yoshizawa, H., Ohkubo, L., Shimura, T., Yasoshima, Y.
Organizer
22nd Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB 2014))
Place of Presentation
Seattle, USA.
Year and Date
2014-07-29 – 2014-08-02
Related Report
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