| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The present project aimed to develop mouse models of hedonically motivated sugar overconsumption and sugar preference. In Study 1, limited access to a highly palatable sucrose solution and chow for 10 days caused binge-like sucrose overconsumption in food-deprived mice. The binge-like behavior was not disrupted by energetic restoration such as systemic administration of glucose and preload of chow, suggesting that the binge-like behavior is driven by hedonic motivation rather than metabolic need. Longer training accelerated its reinstatement after long abstinence. In Study 2, FD mice were alternately exposed sucrose and saccharin. Trained mice increased sucrose intake and preference for sucrose over an equally sweet-tasting non-caloric saccharin. Mice with selective lesions of the basolateral, but not central, amygdala did not show these behavioral preference for sucrose. Our study provides useful mouse models of hedonic motivated sugar overconsumption and preference for sugar reward.
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