| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Tumor-associated macrophages (TAMs) play important roles in tumor development. Previously, we revealed the importance of serine from the extracellular miliue for the differentiation of bone marrow macrophages. In this study, we evaluated the contribution of serine for recruitment and tumor supporting function of TAMs. Suppression of serine biosynthesis or serine transport in mouse tumor cells by microRNA introduction decreased the proliferation of tumor cells in vitro as well as in vivo. Although neither infiltration nor polarization of TAMs were affected by the alteration of production and supply of serine from tumor cells, serine biosynthesis as well as neutral amino acid transporters can be a valid therapeutic targets for the treatment of cancers.
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