Significance of L-serine in intercellular communication between cancer cells and tumor-associated macrophages
Project/Area Number |
24614007
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Integrated Nutrition Science
|
Research Institution | International University of Health and Welfare |
Principal Investigator |
Ogawa Takuya 国際医療福祉大学, 薬学部, 講師 (30457147)
|
Co-Investigator(Kenkyū-buntansha) |
Norihiro Kitagawa 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (30294284)
|
Project Period (FY) |
2012-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | セリン / Phgdh / 腫瘍 / マクロファージ / L-セリン |
Outline of Final Research Achievements |
Tumor-associated macrophages (TAMs) play important roles in tumor development. Previously, we revealed the importance of serine from the extracellular miliue for the differentiation of bone marrow macrophages. In this study, we evaluated the contribution of serine for recruitment and tumor supporting function of TAMs. Suppression of serine biosynthesis or serine transport in mouse tumor cells by microRNA introduction decreased the proliferation of tumor cells in vitro as well as in vivo. Although neither infiltration nor polarization of TAMs were affected by the alteration of production and supply of serine from tumor cells, serine biosynthesis as well as neutral amino acid transporters can be a valid therapeutic targets for the treatment of cancers.
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Report
(5 results)
Research Products
(6 results)
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[Journal Article] Adaptive response to L-serine deficiency is mediated by p38 MAPK activation via 1-deoxysphinganine in normal fibroblasts2016
Author(s)
Tomoko Sayano, Yuki Kawano, Wataru Kusada, Yashiho Arimoto, Kayoko Esaki, Momoko Hamano, Miyako Udono, Yoshinori Katakura, Takuya Ogawa, Hisanori Kato, Yoshio Hirabayashi, Shigeki Furuya
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Journal Title
FEBS Open Bio
Volume: 6
Issue: 4
Pages: 303-316
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Cyclodextrin Complexed [60]Fullerene Derivatives with High Levels of Photodynamic Activity by Long Wavelength Excitation.2013
Author(s)
Ikeda A, Iizuka T, Maekubo N, Aono R, Kikuchi J, Akiyama M, Konishi T, Ogawa T, Ishida-Kitagawa N, Tatebe H, Shiozaki K
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Journal Title
ACS Medicinal Chemistry Letters
Volume: 4
Issue: 8
Pages: 752-756
DOI
Related Report
Peer Reviewed
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[Journal Article] Aberrant gene expression and sexually incompatible genomic imprinting in oocytes derived from XY mouse embryonic stem cells in vitro.2013
Author(s)
Nitta M, Imamura M, Inoue Y, Kunitomo Y, Lin ZY, Ogawa T, Yogo K, Ishida-Kitagawa N, Fukunaga N, Okano H, Sato E, Takeya T, Miyoshi J
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Journal Title
PLoS One
Volume: 8
Issue: 3
Pages: e58555-e58555
DOI
Related Report
Peer Reviewed
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