Application of evidence of the functional relationship between incretin and fish oil to dietary therapy for diabetes

• Project/Area Number: 24614013
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrated Nutrition Science
• Research Institution: Toyo University (2014-2015); National Center for Geriatrics and Gerontology (2012-2013)
• Principal Investigator: Tsunoda Nobuyo 東洋大学, 食環境科学部, 教授 (60337483)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: インクレチン / DPP4 / 魚油 / 糖尿病 / 魚 / DPP4活性 / DPP4量 / EPA / DHA / パルミチン酸 / リノール酸

Outline of Final Research Achievements

The functional relationship between incretin and fish oil was investigated in this study.
In the in vitro study, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are typical components in fish oil, inhibited dipeptidyl-peptidase 4 (DPP4) activity. This result suggested that these inhibitory effects were important contributors to the functional mechanism of fish oil, and that EPA and DHA can regulate DPP4 activity.
A study about the effect of fish oil on DPP4 activity in diabetes is underway. Fifty patients have agreed to participate in this study to date. Once the study is completed, its results can serve as evidence of the effect of fish oil intake on DPP4 activity.