| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Aldehyde dehydrogenase 2 (ALDH2) has a major role in acetaldehyde detoxification and is localized in mitochondria. About half of Japanese and East Asians have a mutant ALDH2 gene, resulting in sensitivity to alcohol. We previously showed that a dominant-negative form of Aldh2 mice showed osteoporosis caused by impaired osteoblastogenesis. In this study, we examined whether or not various nutritional factors have effects of antioxidant reagents to prevent osteoporosis in Aldh2 transgenic (ALDH2-DAL）mice and in their osteoclast cells. As the results, astaxanthin effectively inhibited the failure of osteoblasts to differentiate in a dose-dependent manner. The administration of astaxanthin to ALDH2-DAL mice led to an increasing femur bone density compared to normal-diet ALDH2-DAL mice fed for 3 months in vivo experiments. In this study, we showed that astaxanthin prevented osteoporosis caused by ALDH2 gene mutation.
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