Is the cardiovascular dysfunction with hypomagnesemia improved by magnesium supplemental treatment?
| Project/Area Number |
24614015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IESAKI Takafumi 順天堂大学, 医学部, 准教授 (10348956)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 低マグネシウム血症 / 心血管機能不全 / ミトコンドリア / マグネシウム補充 / マグネシウム欠乏 / 虚血再灌流障害 / 心筋保護 / ミトコンドリア透過性遷移孔(mPTP) / TRPM7チャネル / 突然死 |
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| Outline of Final Research Achievements |
To assess the cardiovascular function of chronic magnesium (Mg) deficient rat and effect of supplementation with Mg, we generated chronic Mg deficient rat model. In chronic Mg deficient rat, cardiovascular function was decreased. Cardiac and vascular dysfunctions were caused by the mitochondrial dysfunction and by the failure of intracellular signaling mechanism through the G protein-coupled receptor, respectively. Mg supplementation will be effective in the improvement of cardiovascular dysfunction by Mg deficiency. It is necessary to detailed studies about the cardiovascular dysfunction and Mg supplementation by Mg deficiency.
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Report
(4 results)
Research Products
(5 results)
