Is the cardiovascular dysfunction with hypomagnesemia improved by magnesium supplemental treatment?

• Project/Area Number: 24614015
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrated Nutrition Science
• Research Institution: Juntendo University
• Principal Investigator: WATANABE Makino 順天堂大学, 医学部, 准教授 (00255655)
• Co-Investigator(Kenkyū-buntansha): IESAKI Takafumi 順天堂大学, 医学部, 准教授 (10348956)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 低マグネシウム血症 / 心血管機能不全 / ミトコンドリア / マグネシウム補充 / マグネシウム欠乏 / 虚血再灌流障害 / 心筋保護 / ミトコンドリア透過性遷移孔(mPTP) / TRPM7チャネル / 突然死

Outline of Final Research Achievements

To assess the cardiovascular function of chronic magnesium (Mg) deficient rat and effect of supplementation with Mg, we generated chronic Mg deficient rat model. In chronic Mg deficient rat, cardiovascular function was decreased. Cardiac and vascular dysfunctions were caused by the mitochondrial dysfunction and by the failure of intracellular signaling mechanism through the G protein-coupled receptor, respectively. Mg supplementation will be effective in the improvement of cardiovascular dysfunction by Mg deficiency. It is necessary to detailed studies about the cardiovascular dysfunction and Mg supplementation by Mg deficiency.

Research Products

• [Journal Article] 低酸素下における心筋細胞内マグネシウムの維持機構 (2013)
  • Author(s): 華藤恵美、中村京子、家崎貴文、岡田隆夫、代田浩之、渡邉マキノ
  • Journal Title: 順天堂醫事雑誌 Volume: 59 Pages: 260-266
  • NAID: 130004712327
  • Peer Reviewed
• [Presentation] Mechanisms of cardioprotective effects of high magnesium on hypoxia/reoxygenation injury in chronic magnesium deficient rat heart are differ from normal rat heart (2014)
  • Author(s): Makino Watanabe, Kyoko Nakamura, Megumi Kato, Ryo Kakigi, Takafumi Iesaki, Takao Okada
  • Organizer: Experimental Biology 2014
  • Place of Presentation: San Diego Convention Center
  • Year and Date: 2014-04-26 – 2014-04-30
• [Presentation] Mechanisms of cardioprotective effects of high concentration of magnesium on hypoxia/reoxygenation injury in chronic magnesium deficient rat heart are differ from normal rat heart (2014)
  • Author(s): Makino Watanabe, Ryo Kakigi, Takafumi Iesaki, Takao Okada
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス
• [Presentation] Mechanisms of cardioprotective effects of high concentration of magnesium on hypoxia/reoxygenation injury in chronic magnesium deficient rat heart are differ from normal rat heart (2014)
  • Author(s): Makino Watanabe, Kyoko Nakamura, Megumi Kato, Ryo Kakigi, Takafumi Iesaki, Takao Okada
  • Organizer: Experimental Biology 2014
  • Place of Presentation: San Diego Convention Center
• [Presentation] Magnesium Influx Pathway in Cardiomyocytes Under Hypoxic Condition (2013)
  • Author(s): Megumi Kato, Kyoko Nakamura, Takafumi Iesaki, Takao Okada, Hiroyuki Daida, Makino Watanabe
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀（東京）