Basic research of hepatic transcription factor as a target for obesity control
| Project/Area Number |
24614020
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKAKIBARA Ryuzo 長崎国際大学, 薬学部, 教授 (30127229)
NODAKE Yuichi 長崎国際大学, 薬学部, 教授 (30332282)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 脂質合成 / 乳酸菌生産物質 / 転写因子 / 肥満予防 / 脂質代謝 / 非アルコール性脂肪肝炎 |
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| Outline of Final Research Achievements |
PS-B1 is fermented products using lactic acid bacteria, which showed inhibitory effect on hepatic transcription factor ChREBP-mediated gene expression in vitro. The present study evaluated the effect of PS-B1 on high sucrose diet-induced obesity in mice. The weight gain of overall body, liver, and visceral fat was reduced in the PS-B1 treated mice in a dose-dependent way. Besides, mRNA expression of hepatic glycolytic and lipogenic enzymes including L-PK, ACC, FAS etc. was significantly lower especially in 5% PS-B1-treated mice. The results of this study suggest that PS-B1 inactivates ChREBP-mediated gene expression, resulting in reduced fat synthesis and obesity in vivo.
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Report
(5 results)
Research Products
(5 results)
