| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Regenerative medicine based on stem cell transplantation is used to treat various conditions such as ischemia and spinal cord injury. In basic studies using small laboratory animals, transplanted cells improve blood flow at infarcted regions, and reconstruct an injured spinal cord and provide motor ability, though some adverse event reports. Therefore, evaluation systems are necessary to evaluate the safety and efficacy of regenerative medicine using large animals. We developed cell-tracking system in a nonhuman primate model to evaluate the safety and efficacy of regenerative medicine. We could reveal the process of labeling with FIP in cells by fluorescent microscopy. Several organs of cynomolgus monkeys emitted MRI signals from the FIP-labeled cells. The cell-tracking system with transplantation of FIP-labeled MSC in nonhuman primates was safe and efficient rather than any other method of regenerative medicine assessment.
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