Development of Cell Tracking System in nonhuman primates
Project/Area Number |
24615009
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Regenerative medicine
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Research Institution | 独立行政法人医薬基盤研究所 |
Principal Investigator |
AGEYAMA Naohide 独立行政法人医薬基盤研究所, 霊長類医科学研究センター, 主任研究員 (50399458)
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Research Collaborator |
FUJISHIRO Yasuyo
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 霊長類 / MRI / 幹細胞 / 再生医療 / 細胞動態 / 磁性体 / 疾患モデル / 移植 / cellular tracking |
Outline of Final Research Achievements |
Regenerative medicine based on stem cell transplantation is used to treat various conditions such as ischemia and spinal cord injury. In basic studies using small laboratory animals, transplanted cells improve blood flow at infarcted regions, and reconstruct an injured spinal cord and provide motor ability, though some adverse event reports. Therefore, evaluation systems are necessary to evaluate the safety and efficacy of regenerative medicine using large animals. We developed cell-tracking system in a nonhuman primate model to evaluate the safety and efficacy of regenerative medicine. We could reveal the process of labeling with FIP in cells by fluorescent microscopy. Several organs of cynomolgus monkeys emitted MRI signals from the FIP-labeled cells. The cell-tracking system with transplantation of FIP-labeled MSC in nonhuman primates was safe and efficient rather than any other method of regenerative medicine assessment.
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Report
(4 results)
Research Products
(16 results)
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[Presentation] 再生医療評価系としてのカニクイザルMSCを用いた細胞標識の解析2014
Author(s)
藤城(伊藤) 康世, 鯉江 洋, 柴田 宏昭, 岡林 佐知, 片貝 祐子, Boran Osman, 金山喜一, 保富康宏, 揚山 直英
Organizer
第61回日本実験動物学会総会(日本実験動物科学技術さっぽろ 2014)
Place of Presentation
北海道札幌市
Year and Date
2014-05-15 – 2014-05-17
Related Report
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[Presentation] Cell tracking in non-human primates using magnetic resonance imaging2013
Author(s)
Yasuyo Ito, Hiroshi Koie, Hiroaki Shibata, Sachi Okabayashi, Yuko Katakai, Chieko Ohno, Kiichi Kanayama, Yasuhiro Yasutomi, Naohide Ageyama
Organizer
64th AALAS National Meeting
Place of Presentation
Baltimore, MD, USA
Related Report
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