Fundamental study for development of biomonitoring system using accurate corona discharges and mass spectrometry
| Project/Area Number |
24619005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
オミクス計測科学
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| Research Institution | Yokohama City University |
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Principal Investigator |
SEKIMOTO Kanako 横浜市立大学, 生命ナノシステム科学研究科, 助教 (40583399)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | コロナ放電 / 質量分析 / 大気イオン / 負イオン / プロトン親和力 / アミノ酸 / ペチュニア / リアルタイム直接分析法（DART) / 反応イオン / 大気反応イオン |
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| Outline of Final Research Achievements |
One of the most interesting topics in omics is the development of in situ analysis techniques for biomolecules. In this study, a biomonitoring system that makes it possible to ionize low molecular weight biomolecules selectively and in situ has been developed using accurate corona discharges and mass spectrometry. The accurate corona discharges lead to the regular formation of atmospheric negative ions with various different gas-phase acidities, which serve as reactant ions to ionize gas-phase analytes via ion-molecule reactions. The system developed here can provide the information about both molecular weight and structure of a given analyte, which contributes towards the application to unknown compound analysis.
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Report
(4 results)
Research Products
(30 results)
