| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Highly accurate and sensitive quantification of serum protein and peptide by mass spectrometry is a key technology which provides the standard value to calibrate and compare the results in clinical chemistry and other research field related to quantification. We performed amino acid analyses of pure C-peptide and C reactive protein with high accuracy, and established certified reference materials of these proteins. To achieve highly accurate and sensitive quantification for serum C-peptide and C reactive protein, we also developed the quantification methods utilizing purification and N-terminal modification methods to enhance the signal intensity.
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