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Influence of microgravity environment on skeletal muscle of zebrafish

Research Project

Project/Area Number 24620005
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field 宇宙生命学
Research InstitutionKyoto University

Principal Investigator

SATO Fuminori  京都大学, 健康長寿社会の総合医療開発ユニット, 特定助教 (10588263)

Co-Investigator(Kenkyū-buntansha) SEHARA Atsuko  京都大学, 再生医科学研究所, 教授 (60209038)
Co-Investigator(Renkei-kenkyūsha) KAWAKAMI Koichi  国立遺伝学研究所, 教授 (70195048)
SUZUKI Yutaka  東京大学, 新領域創成科学研究科, 教授 (40323646)
Research Collaborator UCHIDA Satoko  
TANIGAKI Fumiaki  
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords微重力環境 / ゼブラフィッシュ / 骨格筋 / トランスクリプトーム解析 / 宇宙 / 筋形成・維持
Outline of Final Research Achievements

We performed space stay experiments using zebrafish which are aquatic organisms for analyzing microgravity environment-dependent skeletal muscle atrophy. As a results of transcriptome analysis (comprehensive analysis of gene expression) using a next-generation sequencing, the variation was detected in a number of gene expression in skeletal muscle of space stay zebrafish. This result indicates that the skeletal muscle of zebrafish is affected by microgravity environment similar to that of terrestrial animals. Compared with the variation of gene expression on movement suppression and aging which are generally known to induce skeletal muscle atrophy, there are many differences in variation of gene expression on microgravity environment.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2015 2014 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Roles of ADAM8 in elimination of injured muscle fibers prior to skeletal muscle regeneration2015

    • Author(s)
      D. Nishimura, H. Sakai, T. Sato, F. Sato, S. Nishimura, N. Toyama-Sorimachi, J. W. Bartsch and A. Sehara-Fujisawa
    • Journal Title

      Mech Dev

      Volume: 135 Pages: 58-67

    • DOI

      10.1016/j.mod.2014.12.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Roles of ADAM19 in cranial nerve and blood vessel development2014

    • Author(s)
      Fuminori Sato, Atsuo Kawahara, Hiroyuki Kangawa, Hiroyuki Arai, Kazuya Tsumagari, Shigetomo Fukuhara, Koichi Kawakami, and Atsuko Sehara-Fujisawa.
    • Organizer
      International Vascular Biology Meeting
    • Place of Presentation
      Miyakomesse, Kyoto, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] ゼブラフィッシュの筋維持における増殖因子の役割とその制御2012

    • Author(s)
      佐藤文規・瀬原淳子
    • Organizer
      日本宇宙生物科学会
    • Place of Presentation
      阿波観光ホテル、徳島大学長井記念ホール
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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