| Project/Area Number |
24620005
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
宇宙生命学
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
SATO Fuminori 京都大学, 健康長寿社会の総合医療開発ユニット, 特定助教 (10588263)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SEHARA Atsuko 京都大学, 再生医科学研究所, 教授 (60209038)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KAWAKAMI Koichi 国立遺伝学研究所, 教授 (70195048)
SUZUKI Yutaka 東京大学, 新領域創成科学研究科, 教授 (40323646)
|
|---|
| Research Collaborator |
UCHIDA Satoko
TANIGAKI Fumiaki
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 微重力環境 / ゼブラフィッシュ / 骨格筋 / トランスクリプトーム解析 / 宇宙 / 筋形成・維持 |
|---|
| Outline of Final Research Achievements |
We performed space stay experiments using zebrafish which are aquatic organisms for analyzing microgravity environment-dependent skeletal muscle atrophy. As a results of transcriptome analysis (comprehensive analysis of gene expression) using a next-generation sequencing, the variation was detected in a number of gene expression in skeletal muscle of space stay zebrafish. This result indicates that the skeletal muscle of zebrafish is affected by microgravity environment similar to that of terrestrial animals. Compared with the variation of gene expression on movement suppression and aging which are generally known to induce skeletal muscle atrophy, there are many differences in variation of gene expression on microgravity environment.
|
