• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Radiation effects on the relation between oxidative stress and the neuronal development and function

Research Project

Project/Area Number 24620012
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field 宇宙生命学
Research InstitutionJapan Atomic Energy Agency

Principal Investigator

SAKASHITA Tetsuya  独立行政法人日本原子力研究開発機構, 原子力科学研究部門 量子ビーム応用研究センター, 研究員 (30311377)

Co-Investigator(Kenkyū-buntansha) YANASE Sumino  大東文化大学, スポーツ健康科学部, 准教授 (90249061)
SUZUKI Michiyo  独立行政法人日本原子力研究開発機構, 原子力科学研究部門・量子ビーム応用研究センター, 研究員 (10507437)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords宇宙放射線 / 神経回路 / 学習行動 / モデル生物 / 酸化ストレス / 宇宙放射線生物学
Outline of Final Research Achievements

To achieve the inter-planetary space mission, e.g. Mars mission, it is important to investigate the effects of space radiation exposure on the life system. We aimed to clarify the radiation effects on the relation between oxidative stress and the neuronal function, i.e. learning or behavior. First, we examined the radiation effects on the learning behavior along to the development, resulting on the maximum effects on the adult but early larvae. Next, we tried to the microbeam irradiation to reveal the sensitive area of the nervous network in C. elegans. As a result, we found that the whole body of C. elegans was sensitive to the radiation exposure on learning behavior.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (26 results)

All 2015 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (19 results) Book (1 results)

  • [Journal Article] Detection and meas-urement of abnormal posture under stress-ful conditions in nematode C. elegans.2014

    • Author(s)
      K. Ide, T. Ishikawa, S. Arai, T. Morioka, H. Kaneda, M. Suzuki, T. Sakashita, N. Ishii, S. Yanase
    • Journal Title

      C. elegans Topic Meeting: Aging, Metabolism, Stress, Pathogenesis, and Small RNAs 2014

      Volume: なし Pages: 95-95

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] <i>PAK1</i>-deficiency/down-regulation reduces brood size, activates <i>HSP16.2</i> gene and extends lifespan in <i>Caenorhabditis elegan</i><i>s </i>2013

    • Author(s)
      Yanase S, Luo Y, Maruta H
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 7 Issue: 1 Pages: 29-35

    • DOI

      10.5582/ddt.2013.v7.1.29

    • NAID

      130005054758

    • ISSN
      1881-7831, 1881-784X
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Behavioral Resistance of Caenorhabditis elegans Against High-LET Radiation Exposure2012

    • Author(s)
      Sakashita T, Suzuki M, Hamada N, Shimozawa Y, Shirai-Fukamoto K, Yokota Y, Hamada-Sora S, Kakizaki T, Wada S, Funayama T, Kobayashi Y
    • Journal Title

      Biol Sci Space

      Volume: 26 Pages: 7-11

    • NAID

      130004450620

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Innate immune genes including a mucin-like gene, mul-1, induced by ionizing radiation in Caenorhabditis elegans2012

    • Author(s)
      Kimura T, Takanami T, Sakashita T, Wada S, Kobayashi Y, Higashitani A
    • Journal Title

      Radiat Res

      Volume: 178(4) Issue: 4 Pages: 313-20

    • DOI

      10.1667/rr2989.1

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of Low- and High-LET Radiation on the Salt Chemotaxis Learning in Caenorhabditis elegans2012

    • Author(s)
      Sakashita T, Suzuki M, Hamada N, Shimozawa Y, Shirai-Fukamoto K, Yokota Y, Hamada-Sora S, Kakizaki T, Wada S, Funayama T, Kobayashi Y
    • Journal Title

      Biol Sci Space

      Volume: 26 Pages: 21-25

    • NAID

      130004450622

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Timing mechanism and effective activation energy concerned with aging and lifespan in the long-lived and thermosensory mutants of Caenorhabditis elegans2012

    • Author(s)
      Suda H, Sato K, Yanase S
    • Journal Title

      Mechanisms of Ageing & Development

      Volume: 133 Pages: 600-610

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Responses of the Salt Chemotaxis Learning in Wild Type and Mutant C. elegans to Microbeam Irradiation2015

    • Author(s)
      Sakashita T, Suzuki M, Hattori Y, Ikeda H, Mutou Y, Yokota Y, Funayama T, Hamada N, Shirai K, Kobayashi Y
    • Organizer
      The Fifth International Society of Radiation Neurobiology Conference
    • Place of Presentation
      高崎シティギャラリー(高崎市,日本)
    • Year and Date
      2015-02-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] マイクロビーム照射に対する線虫変異体の化学走性学習の応答2014

    • Author(s)
      坂下哲哉, 鈴木芳代, 服部佑哉, 池田裕子, 武藤泰子, 横田裕一郎, 舟山知夫, 浜田信行, 白井花菜, 小林泰彦, 浜田信行, 白井花菜
    • Organizer
      第9回高崎量子応用研究シンポジウム
    • Place of Presentation
      高崎シティギャラリー(高崎市,日本)
    • Year and Date
      2014-10-09 – 2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 線虫の筋運動に対する炭素イオンマイクロビーム局部照射の影響2014

    • Author(s)
      鈴木 芳代,坂下 哲哉,服部 佑哉,小林 泰彦
    • Organizer
      第9回高崎量子応用研究シンポジウム要旨集
    • Place of Presentation
      高崎シティギャラリー(高崎市,日本)
    • Year and Date
      2014-10-09 – 2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 線虫の行動における生存戦略について ―走性に着目して―2014

    • Author(s)
      坂下哲哉
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      かごしま県民交流センター(鹿児島市,日本)
    • Year and Date
      2014-10-01 – 2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 放射線による線虫の運動抑制における放射線産生ROSの関与2014

    • Author(s)
      鈴木 芳代,坂下 哲哉,服部 佑哉,小林 泰彦
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      かごしま県民交流センター(鹿児島市,日本)
    • Year and Date
      2014-10-01 – 2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 線虫変異体の化学走性学習に対する重イオンマイクロビーム局部照射の影響2014

    • Author(s)
      坂下哲哉, 鈴木芳代, 服部佑哉, 池田裕子, 武藤泰子, 横田裕一郎, 舟山知夫, 浜田信行, 白井花菜, 小林泰彦
    • Organizer
      日本宇宙生物科学会第28回大会
    • Place of Presentation
      大阪府立大学(堺市,日本)
    • Year and Date
      2014-09-22 – 2014-09-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Oxidative stress suppresses locomotion and pumping motion in Caenorhabditis elegans.2014

    • Author(s)
      Michiyo Suzuki, Tetsuya Sakashita, Yuya Hattori, Yasuhiko Kobayashi
    • Organizer
      2014 C. elegans Development, Cell Biology, and Gene Expression Topic Meeting in association with The 6th Asia-Pacific C. elegans Meeting
    • Place of Presentation
      奈良県新公会堂(奈良市,日本)
    • Year and Date
      2014-07-15 – 2014-07-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Detection and meas-urement of abnormal posture under stress-ful conditions in nematode C. elegans.2014

    • Author(s)
      K. Ide, T. Ishikawa, S. Arai, T. Morioka, H. Kaneda, M. Suzuki, T. Sakashita, N. Ishii, S. Yanase
    • Organizer
      C. elegans Topic Meeting: Aging, Metabolism, Stress, Pathogenesis, and Small RNAs
    • Place of Presentation
      ウィスコンシン大学(マディソン市,米国)
    • Year and Date
      2014-07-10 – 2014-07-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Exploration of the site responsible for the radiation response of the salt chemotaxis learning in C. elegans using heavy-ion microbeam2013

    • Author(s)
      Sakashita T, Suzuki M, Mutou Y, Hattori Y, Ikeda H, Yokota Y, Funayama T, Hamada N, Fukamoto K, Kobayashi Y
    • Organizer
      Heavy Ion in Therapy and Space Radiation Symposium 2013
    • Place of Presentation
      京葉銀行文化プラザ(千葉市, 日本)
    • Related Report
      2013 Research-status Report
  • [Presentation] マイクロビーム照射に対するMock条件付け線虫の化学走性の応答2013

    • Author(s)
      坂下哲哉, 下澤容子, 鈴木芳代, 服部佑哉, 池田裕子, 武藤泰子, 横田裕一郎, 舟山知夫, 小林泰彦, 浜田信行, 白井花菜
    • Organizer
      第8回高崎量子応用研究シンポジウム
    • Place of Presentation
      高崎シティギャラリー(高崎市, 日本)
    • Related Report
      2013 Research-status Report
  • [Presentation] Intermittent hyperoxia-induced hormesis decreases aerobic respiration via ins/IGF-1 and p53/CEP-1 signalings in C. elegans2013

    • Author(s)
      Yanase S, Shoyama T, Suda H, Ishii N
    • Organizer
      19th International C. elegans Meeting
    • Place of Presentation
      University of California(ロサンゼルス, 米国)
    • Related Report
      2013 Research-status Report
  • [Presentation] Cell-level modeling and simulation of the pharyngeal pumping in Caenorhabditis elegans2013

    • Author(s)
      Hattori Y, Suzuki M, Tsuji T, Kobayashi Y
    • Organizer
      19th International C. elegans Meeting
    • Place of Presentation
      University of California(ロサンゼルス, 米国)
    • Related Report
      2013 Research-status Report
  • [Presentation] マイクロビームを用いた線虫の化学走性学習に及ぼす放射線影響部位の探索2013

    • Author(s)
      坂下哲哉, 鈴木芳代, 服部佑哉, 池田裕子, 武藤泰子, 横田裕一郎, 舟山知夫, 浜田信行, 深本花菜, 小林泰彦
    • Organizer
      第3回国際放射線神経生物学会大会
    • Place of Presentation
      万国津梁館 (名護市, 日本)
    • Related Report
      2012 Research-status Report
  • [Presentation] マイクロビームを用いた線虫の化学走性学習に及ぼす放射線影響部位の探索2012

    • Author(s)
      坂下哲哉, 鈴木芳代, 服部佑哉, 池田裕子, 武藤泰子, 横田裕一郎, 舟山知夫, 浜田信行, 深本花菜, 小林泰彦
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大学 (仙台市, 日本)
    • Related Report
      2012 Research-status Report
  • [Presentation] 線虫の行動に観られる高LET放射線耐性2012

    • Author(s)
      坂下哲哉, 鈴木芳代, 浜田信行, 下澤容子, 白井花菜, 横田裕一郎, 浜田桜, 柿崎竹彦, 和田成一, 舟山知夫, 小林泰彦
    • Organizer
      第26回日本宇宙生物科学会学術集会
    • Place of Presentation
      阿波観光ホテル (徳島市, 日本)
    • Related Report
      2012 Research-status Report
  • [Presentation] Computational inferences on neurotransmission in chemotaxis learning in Caenorhabditis elegans2012

    • Author(s)
      Michiyo Suzuki, Tetsuya Sakashita, Yasuhiko Kobayashi, Toshio Tsuji
    • Organizer
      EMBO Conference Series: C. elegans Neurobiology
    • Place of Presentation
      EMBL (Heidelberg, Germany)
    • Related Report
      2012 Research-status Report
  • [Presentation] Computational study of neurotransmission in chemotaxis of Caenorhabditis elegans2012

    • Author(s)
      Michiyo Suzuki, Tetsuya Sakashita, Toshio Tsuji, Yasuhiko Kobayashi
    • Organizer
      Foundations of Systems Biology in Engineering (FOSBE) 2012
    • Place of Presentation
      慶応大学鶴岡キャンパス (鶴岡市, 日本)
    • Related Report
      2012 Research-status Report
  • [Presentation] Supplemental cellular protection by a carotenoid astaxanthin extends lifespan via ins/IGF-1 signaling in C. elegans

    • Author(s)
      Yazaki K, Yoshikoshi C, Oshiro S, Takahashi J, Yanase S
    • Organizer
      Aging, Metabolism, Stress, Pathogenesis, and Small RNAs in C. elegans Topic Meeting 2012
    • Place of Presentation
      UW Madison (WI, USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] Supplemental cellular protection by a marine carotenoid extends lifespan via ins/IGF-1 signaling in nematode C. elegans

    • Author(s)
      Yazaki K, Yoshikoshi C, Oshiro S, Takahashi J, Yanase S
    • Organizer
      BIT’s 1st Annual International Congress of Marine Algae-2012
    • Place of Presentation
      World Expo Center (Dalian, China)
    • Related Report
      2012 Research-status Report
  • [Book] PAKs, RAC/CDC42(p21)-activated kinases: Towards the cure of cancer and other PAK-dependent diseases (edited by Hiroshi Maruta) Chapter 7: PAK1 controls the lifespan2013

    • Author(s)
      S. Yanase, H. Maruta
    • Publisher
      Elsevier
    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi