| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
We have carried out the induction of bystander cellular effects, such as cell death and gene mutation, in normal human skin fibroblasts irradiated with the microbeams of different radiation types. We focused on two different pathways of bystander effects, such as gap-junction mediated cell-cell communication and secreate factor(s). The results suggested that the carbon-ion induced bystander effects were dominant via gap-junction mediated cell-cell communication, not secrete factor(s). No bystander effects were observed in X-ray, proton and neon-ion irradiated cells. The argon-ion induced bystander effects were dominant via secrete factor(s) to culture medium from the irradiated cells. There is clear evidence that radiation-induced bystander effects is dependent on radiation quality and the bystander cellular effects are induced by the different mechanisms between carbon- and argon-ion-irradiated cells.
|
