Radiation-quality dependent bystander effects induced by the low-fluence irradiation with heavy ions
| Project/Area Number |
24620014
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
宇宙生命学
|
|---|
| Research Institution | National Institute of Radiological Sciences |
|---|
Principal Investigator |
SUZUKI Masao 独立行政法人放射線医学総合研究所, 重粒子医科学センター, 主任研究員 (70281673)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | マイクロビーム / バイスタンダー効果 / 細胞増殖死 / 遺伝子突然変異 / HPRT遺伝子座 / ギャップジャンクション / 細胞間情報伝達機構 / 液性因子 / 重イオン / 突然変異 / P53 / プロトン |
|---|
| Outline of Final Research Achievements |
We have carried out the induction of bystander cellular effects, such as cell death and gene mutation, in normal human skin fibroblasts irradiated with the microbeams of different radiation types. We focused on two different pathways of bystander effects, such as gap-junction mediated cell-cell communication and secreate factor(s). The results suggested that the carbon-ion induced bystander effects were dominant via gap-junction mediated cell-cell communication, not secrete factor(s). No bystander effects were observed in X-ray, proton and neon-ion irradiated cells. The argon-ion induced bystander effects were dominant via secrete factor(s) to culture medium from the irradiated cells. There is clear evidence that radiation-induced bystander effects is dependent on radiation quality and the bystander cellular effects are induced by the different mechanisms between carbon- and argon-ion-irradiated cells.
|
Report
(4 results)
Research Products
(23 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Cellular response for low-fluence irradiation with HZE-ion beams.2013
Author(s)
Masao Suzuki, Narongchai Autsavapromporn, Tomoo Funayama, Ianik Plante, Yuichiro Yokota, Yasuko Mutou, Michiyo Suzuki, Hiroko Ikeda, Yuya Hattori, Yasuhiko Kobayashi, Takeshi Murakami
Organizer
3rd Asian Congress of Radiation Research
Place of Presentation
北京国際会議場、中国
Related Report
Invited
-
[Presentation] Radiation-quality dependent bystander effects induced by the microbeams with different radiation sources.2013
Author(s)
Masao Suzuki, Narongchai Autsavapromporn, Noriko Usami, Tomoo Funayama, Ianik Plante, Yuichiro Yokota, Yasuko Mutou, Michiyo Suzuki, Hiroko Ikeda, Yuya Hattori, Katsumi Kobayashi, Yasuhiko Kobayashi, Takeshi Murakami
Organizer
Heavy Ion in Therapy and Space Radiation Symposium 2013
Place of Presentation
京葉銀行文化プラザ、千葉市
Related Report
-
-
-
-
-
-
-
-
