Effects of space environments on aging rate and lifespan in C. elegans
| Project/Area Number |
24620016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
宇宙生命学
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
Honda Yoko 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (90399460)
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Shuji 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (40100127)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 宇宙医学 / 線虫 / 老化 / 寿命 / 宇宙 / 老化速度 / 重力 / 遺伝子 / C. elegans / 宇宙環境 |
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| Outline of Final Research Achievements |
Gravity has been an unchanging environmental factor, in which organisms have evolved their biological systems. As space missions are expanding toward manned exploration of, and colonization on, other planets than Earth, organisms including human will have to adapt to such environments for long-term survival. Microgravity during spaceflight have drastic effects on a variety of physiologic functions of mammals including muscle atrophy and bone loss. Some of these effects have been noted to resemble those observed during aging in humans. However, these changes are thought to be essentially reversible because these changes induced by spaceflight have been recovered after return to Earth. However, no reports have been found that examined the lifespan in any experimental animals that lived out their entire life in space. We are investigating the longevity effects of the exposure of Caenorhabditis elegans to space microgravity from the early adult age to death
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Report
(5 results)
Research Products
(17 results)
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[Journal Article] Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans2012
Author(s)
Honda Y, Higashibata A, Matsunaga Y, Yonezawa Y, Kawano T, Higashitani A, Kuriyama K, Shimazu T, Tanaka M, Szewczyk NJ, Ishioka N, Honda S
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Journal Title
Sci Rep
Volume: 2
Issue: 1
Pages: 487-487
DOI
Related Report
Peer Reviewed
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[Presentation] Aging in Space2014
Author(s)
Honda Y, Higashibata A, Matsunaga Y, Yonezawa Y, Kawano T, Higashitani A, Kuriyama K, Shimazu T, Tanaka M, Szewczyk N J, Ishioka N, Honda S
Organizer
C. elegans Development, Cell Biology & Gene Expression Meeting in association with The 6th Asia-Pacific C. elegans Meeting
Place of Presentation
Nara
Year and Date
2014-07-15 – 2014-07-19
Related Report
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[Presentation] Aging in space2014
Author(s)
Yoko Honda, Akira Higashibata, Yohei Matsunaga, Yukiko Yonezawa, Tsuyoshi Kawano, Atsushi Higashitani, Kana Kuriyama, Toru Shimazu, Toko Hashizume, Sachiko Yano, Noriaki Ishioka, Nathaniel J Szewczyk, Masashi Tanaka, & Shuji Honda
Organizer
C. elegans Development, Cell Biology, and Gene Expression Topic Meeting in association with the 6th Asia-Pacific C. elegans Meeting
Place of Presentation
奈良県奈良市
Related Report
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