| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Since aquaporin 4 (AQP4=NMO) antibody were positive, 40 patients were diagnosed as NMO related disorder. Hypothalamic lesions associated with marked or moderate orexin deficiency were found in all cases. Since AQP4 is highly expressed in the hypothalamic regions, an immune attack on AQP4 may be responsible for orexin deficiency. Gaining the basic knowledge of symptomatic narcolepsy in immune mediated conditions will be useful for selecting an appropriate treatment and predicting the prognosis of the disease.
Periodic leg movements during sleep (PLMS) are often associated with restless legs syndrome (RLS). Since, PLMS is also reported in narcoleptic patients, we evaluated CSF ferritin, transferrin and iron in patients with orexin deficient narcolepsy. The patients had higher transferrin and iron levels compared to controls. An increase in transferrin was observed in narcoleptic subjects. Normal ferritin and increased iron levels may possibly suggest a dysregulation of iron metabolites.
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