The etiology of symptomatic narcolepsy and iron metabolites
| Project/Area Number |
24621002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
睡眠科学
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| Research Institution | Akita University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ナルコレプシー / オレキシン / AQP4 / むずむず脚症候群 / 鉄代謝 / アクアポリン4 / 脳内鉄代謝 / 周期性四肢運動障害 / アクアポリン４ |
|---|
| Outline of Final Research Achievements |
Since aquaporin 4 (AQP4=NMO) antibody were positive, 40 patients were diagnosed as NMO related disorder. Hypothalamic lesions associated with marked or moderate orexin deficiency were found in all cases. Since AQP4 is highly expressed in the hypothalamic regions, an immune attack on AQP4 may be responsible for orexin deficiency. Gaining the basic knowledge of symptomatic narcolepsy in immune mediated conditions will be useful for selecting an appropriate treatment and predicting the prognosis of the disease.
Periodic leg movements during sleep (PLMS) are often associated with restless legs syndrome (RLS). Since, PLMS is also reported in narcoleptic patients, we evaluated CSF ferritin, transferrin and iron in patients with orexin deficient narcolepsy. The patients had higher transferrin and iron levels compared to controls. An increase in transferrin was observed in narcoleptic subjects. Normal ferritin and increased iron levels may possibly suggest a dysregulation of iron metabolites.
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Report
(4 results)
Research Products
(69 results)
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[Journal Article] ymptomatic narcolepsy or hypersomnia, with and without hypocretin (orexin) deficiency2015
Author(s)
Kanbayashi T, Imanishi A, Ohmori Y, Sagawa Y, Takahashi Y, Omokawa M, Sato M, Hishikawa Y, Shimizu T, Nishino S
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Journal Title
Narcolepsy, 2nd Edition: A Clinical Guide
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Association between heart rate variability, blood pressure and autonomic activity in cyclic alternating pattern during sleep .2014
Author(s)
Kondo H, Ozone M, Ohki N, Sagawa Y, Yamamichi K, Fukuju M, Yoshida T, Nishi C, Kawasaki A, Mori K, Kanbayashi T, Izumi M, Hi shikawa Y, Nishino S, Shimizu T.
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Journal Title
Sleep.
Volume: 37(1)
Pages: 187-94
Related Report
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[Journal Article] Efficacy, safety and risk of augmentation of rotigotine for treating restless legs syndrome.2013
Author(s)
Inoue Y, Hirata K, Hayashida K, Hattori N, Tomida T, Garcia-Borreguero D, Fujita M, Kousaka M, Ishikawa H, Miura W, Maed a H, Kanbayashi T,etc
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Journal Title
Pro g Neuropsychopharmacol Biol Psychiatry,
Volume: 10(40)
Pages: 326-333
Related Report
Peer Reviewed
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[Journal Article] Rotigotine Study Group. Efficacy, safety and risk of augmentation of rotigotine for treating restless legs syndrome.2013
Author(s)
Inoue Y, Hirata K, Hayashida K, Hattori N, Tomida T, Garcia-Borreguero D, Fujita M, Kousaka M, Ishikawa H, Miura W, Maeda H, Kanbayashi T;
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry.
Volume: 40
Pages: 326-333
DOI
Related Report
Peer Reviewed
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[Journal Article] Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy.2012
Author(s)
Andlauer O, Moore H 4th, Hong SC, Dauvilliers Y, Kanbayashi T, Nishino S, Han F, Silber MH, Rico T, Einen M, Kornum BR, Jennum P, Knudsen S, Nevsimalova S, Poli F, Plazzi G, Mignot E.
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Journal Title
Sleep.
Volume: 35(9)
Issue: 9
Pages: 1247-1255
DOI
Related Report
Peer Reviewed
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[Journal Article] Hypothermia, hypotension, hypersomnia, and obesity associated with hypothalamic lesions in a patient positive for the anti-aquaporin 4 antibody: a case report and literature review.2012
Author(s)
Suzuki K, Nakamura T, Hashimoto K, Miyamoto M, Komagamine T, Nagashima T, Izawa N, Kanbayashi T, Takahashi T, Hirata K.
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Journal Title
Arch Neurol.
Volume: 69(10)
Pages: 1355-1359
Related Report
Peer Reviewed
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[Journal Article] Anti-NMDA-receptor antibody detected in encephalitis, schizophrenia, and narcolepsy with psychotic features2012
Author(s)
K Tsutsui, T Kanbayashi, K Tanaka, S Boku, W Ito, J Tokunaga, A Mori, Y Hishikawa, T Shimizu, S Nishino
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Journal Title
BMC Psychiatry
Volume: 12
Issue: 1
Pages: 37-37
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] A patient with anti-aquaporin 4 antibody presenting hypersomnolence as the initial symptom and symmetrical hypothalamic lesions.2012
Author(s)
Deguchi K, Kono S, Deguchi S, Morimoto N, Ikeda M, Kurata T, Ikeda Y, Matsuura T, Kanbayashi T, Takahashi T, Abe K.
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Journal Title
J Neurol Sci.
Volume: 312(1-2)
Issue: 1-2
Pages: 18-20
DOI
Related Report
Peer Reviewed
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[Presentation] Anti-NMDA-receptor Antibodies Detected in Limbic Encephalitis, Schizophrenia and Narcolepsy with Psychotic Symptoms2014
Author(s)
Takashi Kanbayashi, Kou Tsutsui, Keiko Tanaka, Aya Imanishi, Yohei Sagawa, Mayu Omokawa, Yuki Ohmori, Hiroaki Kusanagi, Seij i Nishino, Tetsuo Shimizu
Organizer
9th International Conference on Early Psychosis
Place of Presentation
京王プラザホテル
Year and Date
2014-11-17 – 2014-11-19
Related Report
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[Presentation] Anti-NMDA-receptor antibody detected in limbic encephalitis, schizophrenia and narcolepsy with psychotic symptoms2014
Author(s)
Takashi Kanbayashi, Kou Tsutsui, Keiko Tanaka, Akane Mori, Aya Imanishi, Yohei Sagawa, Yuka Kikuchi, Eriko Narita, Seiji Nis hino and Tetsuo Shimizu
Organizer
4th Schizophrenia International Research Society Conference
Place of Presentation
Florence, Italy
Year and Date
2014-04-05 – 2014-04-09
Related Report
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[Presentation] APNEA SOUND ANALYSIS BY ACOUSTIC SPECTROGRAPHY AND FAST FOURIER TRANSFORM (FFT) WITH HIGH-RESOLUTION APNEA SOUND DETECTED BY A PIEZOELECTRIC SENSOR2013
Author(s)
Sato, S., Kanbayashi, T., Sagawa, Y., Tokunaga, J., Sato, M., Sakai, N., Shimizu, T., Nishino, S.
Organizer
The 27th Annual Meeting of the Associated Professional Sleep Societies,
Place of Presentation
Baltimore, USA.
Related Report
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[Presentation] LEEP FACILITATION BY ARTIFICIAL CARBONATED BATHING; EEG, CORE, PROXIMAL, AND DISTAL TEMPERATURE EVALUATIONS.2013
Author(s)
Ito, S., Kanbayashi, T., Wakasa, M., Ito, W., Yoshida, M., Shimizu, K., Echizenya, M., Shimizu, T., Nishino, S.
Organizer
The 27th Annual Meeting of the Associated Professional Sleep Societies,
Place of Presentation
Baltimore, USA.
Related Report
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[Presentation] CSF QRFP CONCENTRATIONS IN NARCOLEPSY, NEUROLOGICAL AND PSYCHIATRIC DISORDERS.2013
Author(s)
Kanbayashi, T., Sagawa, Y., Imanishi, A., Takahashi, Y., Suda, H., Takahashi, J., Tokunaga, J., Sato, M., Sato, S., Shimizu, T.
Organizer
The 27th Annual Meeting of the Associated Professional Sleep Societies,
Place of Presentation
Baltimore, USA.
Related Report
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[Presentation] CSF HYPOCRETIN LEVEL IN PATIENTS WITH MYOTONIC DYSTROPHY.2013
Author(s)
Imanishi, A., Kubota, H., Narita, E., Ishikawa, H., Tsutsui, K., Omori, Y., Sasaki, T., Ataka, K., Kanbayashi, T., Shimizu, T.
Organizer
The 27th Annual Meeting of the Associated Professional Sleep Societies,
Place of Presentation
Baltimore, USA.
Related Report
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[Presentation] CSF QRFP Concentrations in Narcolepsy, Neurological and Psychiatric Disorders.2013
Author(s)
Kanbayashi, T., Sagawa, Y., Imanishi, A., Takahashi, Y., Suda, H., Takahashi, J., Tokunaga, J., Sato, M., Sato, S., Shimizu, T.
Organizer
The 27th Annual Meeting of the Associated Professional Sleep Societies,
Place of Presentation
Baltimore, USA.
Related Report
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[Presentation] SYMPTOMATIC NARCOLEPSY AMONG INHERITED DISORDERS, SUCH AS NIEMANN-PICK TYPE C AND MYOTONIC DYSTROPHY TYPE 1.2013
Author(s)
Kanbayashi, T., Imanishi, A., Tokunaga, J., Sagawa, Y., Takahashi, Y., Suda, H., Takahashi, J., Kikuchi, Y., Shimizu, T.
Organizer
Asian narcolepsy symposium
Place of Presentation
Seoul, Korea.
Related Report
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[Presentation] 非定型精神病や精神症状をともなうナルコレプシーにおけるNMDA受容体抗体陽性の症例群2013
Author(s)
神林 崇, 筒井 幸, 田中恵子, 朴 秀賢, 今西 彩, 吉田 祥, 佐川洋平, 須田秀可, 佐藤紳一, 徳永 純, 上村佐知子, 湯浅稚子, 森 朱音, 佐々木倫子, 清水徹男
Organizer
第38回日本睡眠学会定期学術集会
Place of Presentation
秋田キャッスルホテル
Related Report
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[Presentation] 筋強直性ジストロフィー患者における髄液中オレキシン濃度.2013
Author(s)
今西 彩, 久保田弘樹, 佐川洋平, 徳永 純, 筒井 幸, 石川勇仁, 大森佑貴, 佐々木倫子, 安宅慶一郎, 成田恵理子, 高橋 淳, 須田秀可, 高橋裕也, 神林 崇, 清水徹男
Organizer
第38回日本睡眠学会定期学術集会
Place of Presentation
秋田キャッスルホテル
Related Report
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[Presentation] 過眠症状を認めるパーキンソン病と進行性核上性麻痺におけるオレキシン神経系の関与についての検討.2013
Author(s)
高橋裕哉, 徳永 純, 今西 彩, 佐川洋平, 筒井 幸, 伊東若子, 若井正一, 服部優子, 高梨雅史, 油川陽子, 神林 崇, 清水徹男
Organizer
第38回日本睡眠学会定期学術集会
Place of Presentation
秋田キャッスルホテル
Related Report
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[Presentation] CSF biomarkers of narcolepsy, from hypocretin to histamine2012
Author(s)
Kanbayashi T, Sagawa Y, Tokunaga J, Ito W, Sato M, Yagisawa K, Sato S, Imanishi A, Nishino S , Shimizu T.
Organizer
Asian Narcolepsy Forum 2012
Place of Presentation
The Chinese University of Hong Kong
Related Report
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[Presentation] SECONDARY NARCOLEPSY DUE TO NEUROMYELITIS OPTICA, SEVEN CASE SERIES2012
Author(s)
Kanbayashi T, Sagawa Y, Kikuchi Y, Tokunaga J, Ito W, Sato M, Hayashi Y, Takemura T, Aizawa R, Shimizu T
Organizer
SLEEP2012
Place of Presentation
The Hynes Convention Center
Related Report
